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sarcoglycan, delta (dystrophin-associated glycoprotein)

Summary

Gene Symbol

Sgcd

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

24052

PubChem

24052

Alliance of Genome Resources

MGI:1346525

Annotation

Keyword

Cell membrane
Cytoskeleton
Disulfide bond
Glycoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P82347	35 kDa dystrophin-associated glycoprotein
Q544D4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
heart process	IMP	23695275
calcium-mediated signaling	IMP	19931597
protein-containing complex localization	IMP	10481911 17164264
cardiac muscle tissue development	IBA
cardiac muscle cell development	IMP	23695275

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

actin filament-based process [inference]

actin filament-based movement [inference]

actin-mediated cell contraction [inference]

cardiac muscle cell contraction

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

circulatory system process [inference]

heart process

heart contraction

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

coronary vasculature morphogenesis

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

localization [inference]

protein-containing complex localization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cytoskeleton	IEA
plasma membrane	TAS	10448073
plasma membrane	IDA	10481911 16524571 17164264
dystrophin-associated glycoprotein complex	ISO
dystroglycan complex	IDA	10678176

GO Hierarchy

cellular component

protein-containing complex [inference]

glycoprotein complex [inference]

dystrophin-associated glycoprotein complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcolemma

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	12189167 16524571

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sarcoglycan

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cardiac muscle tissue development
heart contraction

Displaying **all 2** entries
InterPro
Sarcoglycan complex subunit protein
Sarcoglycan gamma/delta/zeta

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110280	autosomal recessive limb-girdle muscular dystrophy type 2F	Alliance of Genome Resources
DOID:0110436	dilated cardiomyopathy 1L	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6444	Xenbase:XB-GENE-949518	HUMAN81983
Drosophila melanogaster	6445	FB:FBgn0025391
Xenopus tropicalis	24052	Xenbase:XB-GENE-949518
Drosophila melanogaster	24053	FB:FBgn0025391
Drosophila melanogaster	137868	FB:FBgn0025391
Drosophila melanogaster	244431	FB:FBgn0025391
Danio rerio	324961		DANRE21908
Pan troglodytes	462216		PANTR36676
Rattus norvegicus	497892		RATNO03230
Bos taurus	517059		BOVIN33816

GlyTouCan

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LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements