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arachidonate 5-lipoxygenase

Summary

Gene Symbol

ALOX5

Aliases

5-LOX

Organism

Homo sapiens (human)

External Links

NCBI Gene

240

HGNC

435

KEGG Gene ID

hsa:240

PubChem

240

Alliance of Genome Resources

HGNC:435

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cytoplasm
Dioxygenase
Direct protein sequencing
Hydrolase
Iron
Leukotriene biosynthesis
Lipid metabolism
Membrane
Metal-binding
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P09917	Arachidonate 5-lipoxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 30 in total

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GO Term	Evidence Code	PMID
negative regulation of inflammatory response	IDA	21206090
lipoxygenase pathway	IBA TAS
long-chain fatty acid biosynthetic process
leukocyte migration involved in inflammatory response	ISS
leukocyte chemotaxis involved in inflammatory response	IMP	17114001

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response

leukocyte migration [inference]

leukocyte migration involved in inflammatory response

leukocyte chemotaxis involved in inflammatory response

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

mononuclear cell migration [inference]

dendritic cell migration

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

heterocycle biosynthetic process [inference]

leukotriene A4 biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

fatty acid derivative biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

organic cyclic compound biosynthetic process [inference]

leukotriene A4 biosynthetic process

ether biosynthetic process [inference]

leukotriene A4 biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

heterocycle biosynthetic process [inference]

leukotriene A4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid modification [inference]

lipid oxidation

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

leukotriene A4 biosynthetic process

epoxide metabolic process [inference]

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

fatty acid derivative biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid modification [inference]

lipid oxidation

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

lipoxin metabolic process [inference]

lipoxin biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

ether metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

ether biosynthetic process [inference]

leukotriene A4 biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

fatty acid derivative biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid modification [inference]

lipid oxidation

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

lipoxin metabolic process [inference]

lipoxin biosynthetic process

ether metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

ether biosynthetic process [inference]

leukotriene A4 biosynthetic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic cyclic compound metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

organic cyclic compound biosynthetic process [inference]

leukotriene A4 biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

fatty acid derivative biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

organic cyclic compound biosynthetic process [inference]

leukotriene A4 biosynthetic process

ether biosynthetic process [inference]

leukotriene A4 biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

leukotriene A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

heterocycle biosynthetic process [inference]

leukotriene A4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

leukotriene A4 biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid modification [inference]

lipid oxidation

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

leukotriene A4 biosynthetic process

epoxide metabolic process [inference]

leukotriene A4 metabolic process [inference]

leukotriene A4 biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte migration involved in inflammatory response

leukocyte chemotaxis involved in inflammatory response

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

mononuclear cell migration [inference]

dendritic cell migration

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

multicellular organismal process [inference]

production of molecular mediator involved in inflammatory response [inference]

arachidonic acid metabolite production involved in inflammatory response [inference]

leukotriene production involved in inflammatory response

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

immune response [inference]

humoral immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of reactive oxygen species biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of signaling [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to arterial endothelial cell

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of response to endoplasmic reticulum stress

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing

negative regulation of vascular wound healing

negative regulation of response to wounding [inference]

negative regulation of wound healing

negative regulation of vascular wound healing

negative regulation of response to endoplasmic reticulum stress

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing

negative regulation of vascular wound healing

regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing

negative regulation of vascular wound healing

negative regulation of response to wounding [inference]

negative regulation of wound healing

negative regulation of vascular wound healing

negative regulation of response to endoplasmic reticulum stress

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

negative regulation of wound healing

negative regulation of vascular wound healing

regulation of inflammatory response to wounding

negative regulation of response to wounding [inference]

negative regulation of wound healing

negative regulation of vascular wound healing

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cell differentiation [inference]

regulation of fat cell differentiation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to arterial endothelial cell

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to arterial endothelial cell

regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to arterial endothelial cell

regulation of leukocyte adhesion to arterial endothelial cell [inference]

positive regulation of leukocyte adhesion to arterial endothelial cell

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to arterial endothelial cell

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of cell differentiation [inference]

regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to arterial endothelial cell

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of response to endoplasmic reticulum stress

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

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GO Term	Evidence Code	PMID
nuclear envelope	IBA IDA TAS	19233132
cytosol	IDA TAS	19233132
extracellular region
nuclear matrix	IDA	19233132
secretory granule lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

nuclear membrane

nuclear matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

nuclear envelope lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
hydrolase activity	IEA
arachidonate 12(S)-lipoxygenase activity	IEA
iron ion binding	IDA	21233389
arachidonate 8(S)-lipoxygenase activity	IEA
protein binding	IPI	11297527 16924104 19022417 19233132 24860872 25416956 25910212 26210919 31515488 32296183 32814053 7929073

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

hydrolase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000012779

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00461

Name

arachidonate 5-lipoxygenase [EC:1.13.11.34]

References

Rhea

RHEA:32307

O₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

H₂O + leukotriene A₄

Enzyme

1.13.11.34

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0110746	type 1 diabetes mellitus 7	DisGeNET
DOID:0110747	type 1 diabetes mellitus 8	DisGeNET
DOID:0110748	obsolete type 1 diabetes mellitus 9	DisGeNET
DOID:0110749	type 1 diabetes mellitus 10	DisGeNET
DOID:0110750	type 1 diabetes mellitus 11	DisGeNET
DOID:0110751	type 1 diabetes mellitus 12	DisGeNET
DOID:0110752	type 1 diabetes mellitus 13	DisGeNET
DOID:0110753	type 1 diabetes mellitus 15	DisGeNET
DOID:0110754	type 1 diabetes mellitus 17	DisGeNET
DOID:0110755	type 1 diabetes mellitus 18	DisGeNET

The Human Phenotype Ontology

Displaying **all 3** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0001426	Non-Mendelian inheritance
HP:0002099	Asthma

Displaying 1 entry
Disease ID	Disease Name
OMIM:600807	inherited susceptibility to asthma

PubChem Disease

MedGen Diseases

Inherited susceptibility to asthma

OMIM Phenotypes

ASTHMA, SUSCEPTIBILITY TO

KEGG Diseases

Asthma

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000962
Gene Name: arachidonate 5-lipoxygenase

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ciona intestinalis	100179479		CIOIN02039
Callorhinchus milii	103185827		CALMI33277
Danio rerio	567204	ZFIN:ZDB-GENE-090311-47	DANRE05355
Danio rerio	553602	ZFIN:ZDB-GENE-050522-330
Danio rerio	573013	ZFIN:ZDB-GENE-131219-3
Danio rerio	724056	ZFIN:ZDB-GENE-060623-19
Astyanax mexicanus	103035394		ASTMX02738
Ictalurus punctatus	108263823		ICTPU27026
Electrophorus electricus	113587960		ELEEL03124
Salmo salar	106613187		SALSA70023

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements