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G protein-coupled receptor 158

Summary

Gene Symbol

Gpr158

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

241263

PubChem

241263

Alliance of Genome Resources

MGI:2441697

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Isopeptide bond
Nucleus
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8C419	G-protein coupled receptor 158

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
positive regulation of neurotransmitter secretion	IDA	28851741
G protein-coupled receptor signaling pathway	ISO
G protein-coupled receptor signaling pathway	IDA	22689652 25792749
G protein-coupled receptor signaling pathway	IGI	22689652
brain development	IDA	28851741

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
plasma membrane	ISO
plasma membrane	IDA	30546127
membrane	IDA	22689652
presynaptic membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IDA	28851741
transmembrane signaling receptor activity	IMP	25792749
protein binding	IPI	22689652 30282023
enzyme activator activity	ISO
enzyme activator activity	IDA	25792749

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled glycine receptor activity

neurotransmitter receptor activity [inference]

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled glycine receptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G-protein coupled receptor 158/179
GPCR family 3, C-terminal

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	34642	Xenbase:XB-GENE-950420
Homo sapiens	57512	Xenbase:XB-GENE-950420	HUMAN00589
Drosophila melanogaster	217143	FB:FBgn0264339
Xenopus tropicalis	241263	Xenbase:XB-GENE-950420
Rattus norvegicus	291352		RATNO12961
Drosophila melanogaster	440435	FB:FBgn0264339
Pan troglodytes	466025		PANTR00330
Canis lupus familiaris	477984		CANLF06471
Bos taurus	538123		BOVIN04419
Danio rerio	570001		DANRE26385