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Guidelines

MIRAGE

complement C4A

Summary

Gene Symbol

C4a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24233

PubChem

24233

Alliance of Genome Resources

RGD:620005

Annotation

Keyword

Cleavage on pair of basic residues
Complement pathway
Direct protein sequencing
Disulfide bond
Glycoprotein
Inflammatory response
Phosphoprotein
Reference proteome
Secreted
Signal
Sulfation
Thioester bond

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08649
Q6MG79

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
inflammatory response	IEA
complement activation	ISO
complement activation	TAS	11773063
complement activation	IBA
complement activation, classical pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, classical pathway

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA	8805663
extracellular space	ISO
extracellular space	IDA	15634920
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

Displaying **all 2** entries
GO Term	Evidence Code	PMID
complement component C1q complex binding	ISO
endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

opsonin binding [inference]

complement component C1q complex binding

complement binding [inference]

complement component C1q complex binding

protein-containing complex binding [inference]

complement component C1q complex binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying entries **1 - 10** of 11 in total

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InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin, conserved site
Alpha-2-macroglobulin
Alpha-macroglobulin, receptor-binding domain superfamily
Alpha-macroglobulin, receptor-binding
Alpha-macroglobulin-like, TED domain
Alpha-macroglobulin-like, thiol-ester bond-forming region
Immunoglobulin-like fold
Macroglobulin domain MG3
Macroglobulin domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:15634920

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025