GlyCosmos Portal

Submissions

complement C6

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24237

PubChem

24237

Alliance of Genome Resources

RGD:2238

Annotation

Keyword

Calcium
Disulfide bond
EGF-like domain
Glycoprotein
Membrane attack complex
Metal-binding
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Sushi
Target cell membrane
Transmembrane beta strand

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q811M5
F1M7F7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	ISO
in utero embryonic development	IEA
positive regulation of activation of membrane attack complex
complement activation	ISO
complement activation	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, classical pathway

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

cellular process [inference]

cell killing [inference]

killing of cells of another organism

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
membrane attack complex	ISO
membrane attack complex	IBA
membrane attack complex	IEA
extracellular space	IDA	8089494

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical entity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement C6

Functional Category

K: Transcription
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
complement activation, classical pathway
complement activation
immune response
immune system process

Displaying entries **1 - 10** of 13 in total

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InterPro
Complement component C6, KAZAL domain
Complement components C8A/B/C6, EGF-like domain
Factor I / membrane attack complex
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin domain, conserved site
Membrane attack complex component/perforin/complement C9
Sushi/SCR/CCP domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:8089494

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2921	glomerulonephritis	Alliance of Genome Resources
DOID:576	proteinuria	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources