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WASP family, member 2

Summary

Gene Symbol

Wasf2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

242687

PubChem

242687

Alliance of Genome Resources

MGI:1098641

Annotation

Keyword

Actin-binding
Cell membrane
Cell projection
Cytoskeleton
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BH43	Protein WAVE-2 Wiskott-Aldrich syndrome protein family member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
angiogenesis	IMP	12879075
ameboidal-type cell migration	IMP	12879075
neuron migration	IDA	29911975
endocytosis	IDA	12446704
positive regulation of lamellipodium assembly	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

actin filament-based movement

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cell motility

cell migration [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

postsynapse organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

regulation of lamellipodium organization [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
ruffle	IDA	12446704
intracellular anatomical structure	ISO	17101133
early endosome	IDA	12446704
cytoskeleton	IEA
cell-cell junction	IDA	23793062

GO Hierarchy

cellular component

protein-containing complex

SCAR complex

cellular anatomical entity [inference]

intracellular anatomical structure

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

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GO Term	Evidence Code	PMID
actin binding	IEA
protein binding	IPI	15102471 18044991 20697350
SH3 domain binding	ISO
SH3 domain binding	IEA
protein kinase A regulatory subunit binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

protein domain specific binding [inference]

SH3 domain binding

protein kinase A binding

protein kinase A regulatory subunit binding

protein-containing complex binding [inference]

Arp2/3 complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Wiskott-Aldrich syndrome protein family member 2

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Arp2/3 complex binding
actin binding
actin cytoskeleton organization
positive regulation of Arp2/3 complex-mediated actin nucleation
protein kinase A regulatory subunit binding

Displaying **all 2** entries
InterPro
SCAR/WAVE family
WH2 domain

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	8936	FB:FBgn0041781
Homo sapiens	10163	Xenbase:XB-GENE-5953840	HUMAN48366
Drosophila melanogaster	83767	FB:FBgn0041781
Xenopus tropicalis	242687	Xenbase:XB-GENE-5953840
Drosophila melanogaster	294568	FB:FBgn0041781
Rattus norvegicus	313024		RATNO32628
Danio rerio	394056		DANRE15506
Pan troglodytes	456675		PANTR20386
Canis lupus familiaris	487343		CANLF06964
Macaca mulatta	716082		MACMU25027

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements