GlyCosmos Portal

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glutamate ionotropic receptor kainate type subunit 4

Summary

Gene Symbol

Grik4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24406

PubChem

24406

Alliance of Genome Resources

RGD:2734

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140TAG0
Q01812	Glutamate receptor KA-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
regulation of postsynaptic membrane potential	IEA
ion transmembrane transport	IEA
ionotropic glutamate receptor signaling pathway	IEA
monoatomic ion transport	TAS	7527545
ion transport	TAS	7527545

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of biological quality [inference]

regulation of membrane potential [inference]

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
membrane	ISO
postsynaptic membrane	IEA ISO
postsynaptic density membrane	IBA
terminal bouton	IDA	15844209 16360275
kainate selective glutamate receptor complex	IBA IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

glutamatergic synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

presynapse [inference]

terminal bouton

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA ISO
kainate selective glutamate receptor activity	IBA TAS	7527545
glutamate-gated receptor activity	IDA TAS	25139762 7527545 9390526
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA
signaling receptor activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

amide transmembrane transporter activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

salt transmembrane transporter activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Ionotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis

Displaying **all 7** entries
Gene Ontology
kainate selective glutamate receptor activity
ligand-gated monoatomic ion channel activity
modulation of chemical synaptic transmission
monoatomic ion channel activity
monoatomic ion transport
synaptic transmission, glutamatergic
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 6** entries
InterPro
Ionotropic glutamate receptor, C-terminal
Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Ionotropic glutamate receptor, metazoa
Ionotropic glutamate receptor
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
perikaryon	PMID:15844209
terminal bouton	PMID:15844209 PMID:16360275
dendrite	PMID:15844209
axon	PMID:15844209

Ortholog

Displaying entries **1 - 10** of **126** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2900		HGNC:4582	HUMAN09889
Drosophila melanogaster	33275		FB:FBgn0046113
Drosophila melanogaster	33788		FB:FBgn0004620
Drosophila melanogaster	33789		FB:FBgn0020429
Drosophila melanogaster	35394		FB:FBgn0026255
Drosophila melanogaster	42473		FB:FBgn0038837
Drosophila melanogaster	42476		FB:FBgn0038840
Drosophila melanogaster	43806		FB:FBgn0039916
Drosophila melanogaster	44483		FB:FBgn0028422
Mus musculus	110637	10090_1:002f56	MGI:95817	MOUSE61992