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glutamate metabotropic receptor 3

Summary

Gene Symbol

Grm3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24416

PubChem

24416

Alliance of Genome Resources

RGD:2744

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6K223
A0A8I6GM70
P31422

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IEA
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
G protein-coupled glutamate receptor signaling pathway	IBA
gene expression	ISO
gene expression	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular response to stimulus [inference]

cellular response to stress

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

response to stimulus [inference]

response to stress [inference]

cellular response to stress

cellular response to stimulus [inference]

cellular response to stress

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
postsynaptic density	ISO
postsynaptic density	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

neuron spine [inference]

dendritic spine

glial cell projection [inference]

astrocyte projection

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

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GO Term	Evidence Code	PMID
group II metabotropic glutamate receptor activity	ISO
group II metabotropic glutamate receptor activity	IMP	12694929
group II metabotropic glutamate receptor activity	IBA
group II metabotropic glutamate receptor activity	IEA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

scaffold protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group II metabotropic glutamate receptor activity

glutamate receptor activity [inference]

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group II metabotropic glutamate receptor activity

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

metabotropic glutamate receptor 3

Functional Category

F: Nucleotide transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
cell communication
group II metabotropic glutamate receptor activity
regulation of synaptic transmission, glutamatergic

Displaying **all 9** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, conserved site
GPCR, family 3, metabotropic glutamate receptor 3
GPCR, family 3, metabotropic glutamate receptor
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
astrocyte projection	PMID:21753079

Ortholog

Displaying entries **1 - 10** of **100** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	2912	FB:FBgn0019985
Homo sapiens	2913	Xenbase:XB-GENE-977445	HUMAN89643
Caenorhabditis elegans	2914	WB:WBGene00003232
Caenorhabditis elegans	2916	WB:WBGene00003232
Caenorhabditis elegans	2917	WB:WBGene00003232
Caenorhabditis elegans	2918	WB:WBGene00003232
Caenorhabditis elegans	14823	WB:WBGene00003232
Drosophila melanogaster	24415	FB:FBgn0019985
Xenopus tropicalis	24416	Xenbase:XB-GENE-977445
Caenorhabditis elegans	24417	WB:WBGene00003232

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OrthoDB (Group)

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Acknowledgements