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haptoglobin

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24464

PubChem

24464

Alliance of Genome Resources

RGD:2825

Annotation

Keyword

Acute phase
Alternative splicing
Antibiotic
Antioxidant
Direct protein sequencing
Disulfide bond
Glycoprotein
Hemoglobin-binding
Immunity
Reference proteome
Secreted
Serine protease homolog
Signal
Sushi

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IZ24
P06866	Liver regeneration-related protein LRRG173

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
response to dimethyl sulfoxide	IEP	14757319
proteolysis	IEA
response to organic cyclic compound	IEP	15856910
response to bacterium	ISO
animal organ regeneration	IEP	12379430

GO Hierarchy

biological process

immune system process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cellular detoxification [inference]

cellular oxidant detoxification

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

gland development [inference]

liver development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

response to hypoxia

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

defense response to other organism [inference]

defense response to bacterium

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to starvation

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

response to X-ray

response to electrical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to growth hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to growth hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to organonitrogen compound [inference]

response to cobalamin

response to peptide [inference]

response to peptide hormone [inference]

response to growth hormone

response to organic cyclic compound

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to inorganic substance [inference]

response to metal ion [inference]

response to hydrogen peroxide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to cobalamin

response to peptide [inference]

response to peptide hormone [inference]

response to growth hormone

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to peptide [inference]

response to peptide hormone [inference]

response to growth hormone

response to salt [inference]

response to L-ascorbic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity

regulation of oxidoreductase activity [inference]

negative regulation of oxidoreductase activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 4** entries
GO Term	Evidence Code	PMID
haptoglobin-hemoglobin complex	ISO
extracellular region	IEA
blood microparticle	IDA	22014850
extracellular space	IBA IDA ISO	17161237

GO Hierarchy

cellular component

protein-containing complex [inference]

haptoglobin-hemoglobin complex

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
hemoglobin binding	IDA IEA ISO	6279649
antioxidant activity	IEA
identical protein binding	IPI	6863267
serine-type endopeptidase activity	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

antioxidant activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

haptoglobin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
acute-phase response
antioxidant activity
cellular oxidant detoxification
hemoglobin binding
proteolysis
serine-type endopeptidase activity
zymogen activation

Displaying **all 7** entries
InterPro
Haptoglobin
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
blood microparticle	PMID:22014850
extracellular space	PMID:17161237

Disease

Disease Ontology

Displaying entries **11 - 20** of 41 in total

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DO ID	Disease Name	Source
DOID:12241	beta thalassemia	Alliance of Genome Resources
DOID:12554	hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:13189	gout	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:13378	Kawasaki disease	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:14067	Plasmodium falciparum malaria	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3240		HGNC:5141	HUMAN29651
Homo sapiens	3250		HGNC:5156	HUMAN29666
Mus musculus	15439	10090_1:002c1f	MGI:96211	MOUSE57964
Bos taurus	280692			BOVIN10728
Sus scrofa	397061			PIGXX27148
Canis lupus familiaris	479668			CANLF15993
Danio rerio	566096		ZFIN:ZDB-GENE-030131-1259	DANRE41173
Macaca mulatta	706936			MACMU26470
Macaca mulatta	709274			MACMU26456
Pan troglodytes	745555			PANTR12819

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements