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5-hydroxytryptamine receptor 1A

Summary

Gene Symbol

Htr1a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24473

PubChem

24473

Alliance of Genome Resources

RGD:2845

Annotation

Keyword

Behavior
Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P19327	Serotonin receptor 1A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
behavioral fear response	ISS
behavioral fear response	ISO
G protein-coupled receptor signaling pathway	ISO
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

ammonium ion metabolic process [inference]

serotonin metabolic process

organonitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

primary amino compound metabolic process [inference]

serotonin metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

organonitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

primary amino compound metabolic process [inference]

serotonin metabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

serotonin receptor signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

behavior [inference]

behavioral defense response [inference]

behavioral fear response

adult behavior [inference]

behavioral response to nicotine

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to isoquinoline alkaloid [inference]

response to morphine

response to organic cyclic compound [inference]

response to isoquinoline alkaloid [inference]

response to morphine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to isoquinoline alkaloid [inference]

response to morphine

response to oxygen-containing compound [inference]

response to salt [inference]

response to morphine

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

NMDA glutamate receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of signaling [inference]

regulation of hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion

regulation of secretion [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of secretion by cell [inference]

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amine transport [inference]

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

serotonin receptor signaling pathway

regulation of cell communication [inference]

regulation of hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

regulation of cellular metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of protein-containing complex disassembly [inference]

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of protein depolymerization [inference]

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of secretion by cell [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of behavior

regulation of feeding behavior

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
dendrite	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

GABA-ergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

axon hillock

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	ISO
G-protein alpha-subunit binding	IPI	16772521
G protein-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	IDA	8271204
G protein-coupled serotonin receptor activity	IMP	12149253

GO Hierarchy

molecular function

binding [inference]

protein binding

G-protein alpha-subunit binding

signaling receptor binding

receptor-receptor interaction

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
axon hillock	PMID:18622042
neuronal cell body	PMID:18622042

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:594	panic disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3350	Xenbase:XB-GENE-984750	HUMAN79340
Drosophila melanogaster	3351	FB:FBgn0263116
Drosophila melanogaster	3352	FB:FBgn0263116
Drosophila melanogaster	3354	FB:FBgn0263116
Caenorhabditis elegans	3355	WB:WBGene00004779
Mus musculus	15550	Xenbase:XB-GENE-984750	MOUSE11057
Caenorhabditis elegans	15551	WB:WBGene00004779
Caenorhabditis elegans	15552	WB:WBGene00004779
Caenorhabditis elegans	15557	WB:WBGene00004779
Xenopus tropicalis	24473	Xenbase:XB-GENE-984750

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Acknowledgements