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lactate dehydrogenase A

Summary

Gene Symbol

Ldha

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24533

PubChem

24533

Alliance of Genome Resources

RGD:2996

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Isopeptide bond
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P04642	LDH muscle subunit
B5DEN4
A0A8I5ZX39

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 18 in total

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GO Term	Evidence Code	PMID
pyruvate metabolic process	IBA ISO
response to organic cyclic compound	IEP	7758843
positive regulation of apoptotic process	IDA	9465046
glucose catabolic process to lactate via pyruvate	ISO
response to hydrogen peroxide	IEP	16154111

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

pyruvate metabolic process

pyruvate catabolic process

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

fermentation [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

glycolytic fermentation [inference]

glucose catabolic process to lactate via pyruvate

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

pyruvate metabolic process

pyruvate catabolic process

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

pyruvate metabolic process

pyruvate catabolic process

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

organic hydroxy compound metabolic process [inference]

lactate metabolic process

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

pyruvate metabolic process

pyruvate catabolic process

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

fermentation [inference]

glucose catabolic process to lactate [inference]

glucose catabolic process to lactate via pyruvate

glycolytic fermentation [inference]

glucose catabolic process to lactate via pyruvate

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

pyruvate catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process

cellular response to stimulus [inference]

cellular response to extracellular stimulus

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

animal organ development [inference]

gland development [inference]

liver development

neural nucleus development [inference]

substantia nigra development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

cellular response to extracellular stimulus

cellular response to external stimulus [inference]

cellular response to extracellular stimulus

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to estrogen

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound

response to purine-containing compound [inference]

response to cAMP

response to hydrogen peroxide

response to organophosphorus [inference]

response to cAMP

response to inorganic substance [inference]

response to hydrogen peroxide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to cAMP

cellular response to stimulus [inference]

cellular response to extracellular stimulus

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	ISO
cytoplasm	IEA
oxidoreductase complex	ISO
mitochondrion	IBA
sperm fibrous sheath	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
L-lactate dehydrogenase activity	IBA IDA IEA ISO	17447164
kinase binding	IPI	17572440
NAD binding	IDA	17447164
lactate dehydrogenase activity	IDA ISO	6849973 7138505
protein binding	IPI	7138505

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

lactate dehydrogenase activity

L-lactate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

L-lactate dehydrogenase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	174798	WB:WBGene00002262
Drosophila melanogaster	45880	FB:FBgn0001258
Ciona intestinalis	100174998		CIOIN04295
Danio rerio	30496	ZFIN:ZDB-GENE-991026-5
Xenopus tropicalis	394758	Xenbase:XB-GENE-480608
Chrysemys picta bellii	101953234		CHRPI16866
Crocodylus porosus	109321459		CROPO08705
Pseudonaja textilis	113440255		PSETE11994
Serinus canaria	103826768		SERCA04818
Ornithorhynchus anatinus	791112		ORNAN19246

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Acknowledgements