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mannose binding lectin 1

Summary

Gene Symbol

Mbl1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24548

PubChem

24548

Alliance of Genome Resources

RGD:3055

Annotation

Keyword

3D-structure
Calcium
Coiled coil
Collagen
Complement activation lectin pathway
Complement pathway
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydroxylation
Mannose-binding
Metal-binding
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6K9L8
P19999	Mannan-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
complement activation, lectin pathway	ISO
complement activation, lectin pathway	IDA	16272342
complement activation, classical pathway	IEA
surfactant homeostasis	IBA
positive regulation of phagocytosis	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

activation of immune response [inference]

complement activation [inference]

immune response [inference]

humoral immune response [inference]

complement activation [inference]

innate immune response [inference]

complement activation, lectin pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

chemical homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

killing by host of symbiont cells

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

complement activation, lectin pathway

killing by host of symbiont cells

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

complement activation, lectin pathway

killing by host of symbiont cells

immune response [inference]

humoral immune response [inference]

complement activation [inference]

innate immune response [inference]

complement activation, lectin pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

complement activation, lectin pathway

killing by host of symbiont cells

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

complement activation, lectin pathway

killing by host of symbiont cells

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
collagen trimer	IEA
extracellular space	ISO
extracellular space	IDA	10903744
extracellular space	IBA
multivesicular body	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protease binding	IDA	16272342
calcium ion binding	IDA	10913141 11850428
protein binding	IPI	20118239
mannose binding	IDA	11850428 16272342 22167201
polysaccharide binding	IDA	16272342

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

calcium-dependent protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-4-phosphate binding

carbohydrate binding [inference]

polysaccharide binding

monosaccharide binding [inference]

mannose binding

small molecule binding [inference]

monosaccharide binding [inference]

mannose binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lectin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
C-type lectin fold
C-type lectin-like/link domain superfamily
C-type lectin-like

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:10903744

Ortholog

Displaying entries **1 - 10** of 30 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	4153	ZFIN:ZDB-GENE-000427-2
Danio rerio	6441	ZFIN:ZDB-GENE-000427-2
Mus musculus	17194	ZFIN:ZDB-GENE-070912-287	MOUSE14342
Danio rerio	17195	ZFIN:ZDB-GENE-070912-286
Danio rerio	20390	ZFIN:ZDB-GENE-070912-287
Danio rerio	24548	ZFIN:ZDB-GENE-070912-286
Danio rerio	25350	ZFIN:ZDB-GENE-070912-287
Danio rerio	34162	ZFIN:ZDB-GENE-070912-287
Bos taurus	497014		BOVIN22630
Macaca mulatta	707965		MACMU45147