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MIRAGE
MET proto-oncogene, receptor tyrosine kinase
Summary
- Gene Symbol
-
- Met
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- ATP-binding
- Disulfide bond
- Glycoprotein
- Phosphoprotein
- Proto-oncogene
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A9K3Y8B9 |
|
| P97523 |
|
| Q2IBC7 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| neuron migration | ||
| neuron migration | ||
| endothelial cell morphogenesis | ||
| endothelial cell morphogenesis |
GO Hierarchy
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- semaphorin-plexin signaling pathway
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- semaphorin-plexin signaling pathway
biological process
metabolic process [inference]
cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
cellular response to stimulus [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cellular component biogenesis [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular space | ||
| plasma membrane | ||
| basal plasma membrane | ||
| basal plasma membrane | ||
| basal plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein kinase activity | ||
| protein tyrosine kinase activity | ||
| transmembrane receptor protein tyrosine kinase activity | ||
| GPI-linked ephrin receptor activity | ||
| transmembrane-ephrin receptor activity |
GO Hierarchy
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- semaphorin receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
catalytic activity, acting on a protein [inference]
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
binding [inference]
molecular transducer activity [inference]
signaling receptor activity [inference]
transmembrane signaling receptor activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Tyrosine- kinase
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| nucleotide binding |
| transmembrane receptor protein tyrosine kinase activity |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| InterPro |
|---|
| IPT domain |
| Immunoglobulin E-set |
| Immunoglobulin-like fold |
| PSI domain |
| Plexin repeat |
| Protein kinase domain |
| Protein kinase, ATP binding site |
| Protein kinase-like domain superfamily |
| Sema domain superfamily |
| Sema domain |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 103179355 | CALMI17640 | ||
| 103226771 | CHLSB09904 | ||
| 103268739 | CARSF08850 | ||
| 103676585 | URSMA18803 | ||
| 103737431 | NANGA10916 | ||
| 103813465 | SERCA06152 | ||
| 104682633 | RHIRO10987 | ||
| 105300269 | PTEVA12064 | ||
| 105475620 | MACNE22403 | ||
| 105553697 | MANLE27304 |
