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ATP binding cassette subfamily C member 1

Summary

Gene Symbol

Abcc1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24565

PubChem

24565

Alliance of Genome Resources

RGD:3112

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Glycoprotein
Hydrolase
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CG09	ATP-binding cassette sub-family C member 1 Glutathione-S-conjugate-translocating ATPase ABCC1 Leukotriene C(4) transporter

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
lipid transport	IEA
response to oxidative stress	IMP	11208926
response to xenobiotic stimulus	ISO
response to xenobiotic stimulus	IDA	14641820
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

astrocyte differentiation

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

transmembrane transport

glutathione transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

astrocyte differentiation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

vitamin transport [inference]

cobalamin transport

transmembrane transport

glutathione transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

transepithelial transport

organic substance transport [inference]

lipid transport

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

phospholipid transport [inference]

lipid translocation [inference]

lipid import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

organic anion transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

icosanoid transport [inference]

leukotriene transport

carboxylic acid transmembrane transport

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organophosphate ester transport [inference]

nucleotide transport [inference]

cyclic nucleotide transport

phospholipid transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

icosanoid transport [inference]

leukotriene transport

carboxylic acid transmembrane transport

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

cobalamin transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

cyclic nucleotide transport

nitrogen compound transport [inference]

cobalamin transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

cyclic nucleotide transport

sphingolipid translocation

import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of response to drug [inference]

regulation of cellular response to drug

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular response to drug

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IEA
basal plasma membrane	ISO
basal plasma membrane	IDA	18619525
basal plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

lateral plasma membrane

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GO Term	Evidence Code	PMID
long-chain fatty acid transporter activity	IDA	12867490
ATP binding	IEA
ABC-type xenobiotic transporter activity	IDA	12867490
ABC-type xenobiotic transporter activity	IMP	12893836
ABC-type xenobiotic transporter activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled lipid transmembrane transporter activity

ABC-type transporter activity

amide transmembrane transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

vitamin transmembrane transporter activity [inference]

ABC-type vitamin B12 transporter activity

sulfur compound transmembrane transporter activity [inference]

ABC-type glutathione S-conjugate transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled lipid transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
basolateral plasma membrane	PMID:11804835 PMID:17854063

Rhea

RHEA:19121

H₂O + ATP + an S-substituted glutathione

H⁺ + phosphate + ADP + an S-substituted glutathione

Enzyme

7.6.2.3

PMID

RHEA:33147

H₂O + ATP + daunorubicin

H⁺ + phosphate + ADP + daunorubicin

Enzyme

7.6.2.2

PMID

9281595

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012416
Gene Name: ATP-binding cassette, subfamily C (CFTR/MRP), member 1

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	368	SGD:S000003938
Saccharomyces cerevisiae S288C	1244	SGD:S000002542
Homo sapiens	4363	Xenbase:XB-GENE-960171	HUMAN26860
Saccharomyces cerevisiae S288C	8714	SGD:S000002542
Saccharomyces cerevisiae S288C	12780	SGD:S000003938
Mus musculus	17250	Xenbase:XB-GENE-960171	MOUSE17577
Xenopus tropicalis	24565	Xenbase:XB-GENE-960171
Saccharomyces cerevisiae S288C	25303	SGD:S000003938
Saccharomyces cerevisiae S288C	27421	SGD:S000003938
Saccharomyces cerevisiae S288C	76408	SGD:S000002542

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements