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phospholipid phosphatase 2

Summary

Gene Symbol

Plpp2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

246115

PubChem

246115

Alliance of Genome Resources

RGD:628893

Annotation

Keyword

Cell membrane
Endoplasmic reticulum
Endosome
Glycoprotein
Hydrolase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6K909
Q8K593	Lipid phosphate phosphohydrolase 2 PAP2-gamma Phosphatidate phosphohydrolase type 2c Phosphatidic acid phosphatase 2c
A6K910

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
phospholipid metabolic process	ISS
phospholipid metabolic process	ISO
phospholipid metabolic process	IBA
phospholipid metabolic process	IEA
sphingosine metabolic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cell cycle phase transition [inference]

regulation of cell cycle G1/S phase transition

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
early endosome	ISS
early endosome	ISO
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
phosphatidate phosphatase activity	ISS
phosphatidate phosphatase activity	ISO
phosphatidate phosphatase activity	NAS	10992322
phosphatidate phosphatase activity	IBA
sphingosine-1-phosphate phosphatase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

lipid phosphatase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatidate phosphatase

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
phospholipid dephosphorylation
phospholipid metabolic process

Displaying **all 3** entries
InterPro
Phosphatidate (PA) phosphatase-related
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
Phosphatidic acid phosphatase type 2/haloperoxidase

Rhea

RHEA:27429

H₂O + a 1,2-diacyl-sn-glycero-3-phosphate

a 1,2-diacyl-sn-glycerol + phosphate

Enzyme

3.1.3.4

PMID

RHEA:36239

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphate

phosphate + 1-O-alkyl-2-acyl-sn-glycerol

Enzyme

3.1.3.4

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012968
Gene Name: phosphatidic acid phosphatase type 2c

Ortholog

Displaying entries **1 - 10** of 99 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	8611	FB:FBgn0041087
Homo sapiens	8612	Xenbase:XB-GENE-5816438	HUMAN39157
Drosophila melanogaster	8613	FB:FBgn0041087
Drosophila melanogaster	19012	FB:FBgn0041087
Xenopus tropicalis	35966	Xenbase:XB-GENE-5816438
Mus musculus	50784	Xenbase:XB-GENE-5816438	MOUSE02578
Drosophila melanogaster	67916	FB:FBgn0041087
Xenopus tropicalis	246115	Xenbase:XB-GENE-5816438
Danio rerio	335485		DANRE23522
Pan troglodytes	455525		PANTR16549

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements