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sorbitol dehydrogenase

Summary

Gene Symbol

Sord

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24788

PubChem

24788

Alliance of Genome Resources

RGD:3734

Annotation

Keyword

Acetylation
Carbohydrate metabolism
Flagellum
Membrane
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6HPS1	L-iditol 2-dehydrogenase Polyol dehydrogenase Xylitol dehydrogenase
A0A8I6A2A0	L-iditol 2-dehydrogenase Polyol dehydrogenase Xylitol dehydrogenase
P27867	L-iditol 2-dehydrogenase Polyol dehydrogenase Xylitol dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
sorbitol metabolic process	ISO
sorbitol catabolic process	ISO
sorbitol catabolic process	IBA
sorbitol catabolic process	IEA
response to xenobiotic stimulus	IEP	15064821

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone

response to inorganic substance [inference]

response to metal ion [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IEA
cytosol	ISO
cytosol	IEA
membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

organelle membrane [inference]

mitochondrial membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
L-iditol 2-dehydrogenase activity	ISO
L-iditol 2-dehydrogenase activity	IBA
L-iditol 2-dehydrogenase activity	IEA
zinc ion binding	ISO
zinc ion binding	IDA	11306057

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hexitol dehydrogenase activity [inference]

D-xylulose reductase activity

D-sorbitol dehydrogenase (acceptor) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SORBITOL DEHYDROGENASE

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
L-iditol 2-dehydrogenase activity
metal ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
sorbitol catabolic process
zinc ion binding

Displaying **all 7** entries
InterPro
Alcohol dehydrogenase, zinc-type, conserved site
Alcohol dehydrogenase-like, C-terminal
Alcohol dehydrogenase-like, N-terminal
GroES-like superfamily
NAD(P)-binding domain superfamily
Polyketide synthase, enoylreductase domain
Sorbitol dehydrogenase-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9743	diabetic neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6652	Xenbase:XB-GENE-1005865	HUMAN22836
Mus musculus	20322	Xenbase:XB-GENE-1005865	MOUSE32862
Xenopus tropicalis	24788	Xenbase:XB-GENE-1005865
Pan troglodytes	453394		PANTR10211
Canis lupus familiaris	487535		CANLF12475
Bos taurus	508954		BOVIN01428
Danio rerio	570613		DANRE40437
Macaca mulatta	712784		MACMU40645
Xenopus tropicalis	850759	Xenbase:XB-GENE-1005865
Xenopus tropicalis	851351	Xenbase:XB-GENE-1005865

GlyTouCan

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Annotation

OrthoDB (Group)

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Acknowledgements