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sorbitol dehydrogenase

Summary

Gene Symbol

Sord

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24788

PubChem

24788

Alliance of Genome Resources

RGD:3734

Annotation

Keyword

Acetylation
Carbohydrate metabolism
Flagellum
Membrane
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6HPS1	L-iditol 2-dehydrogenase Polyol dehydrogenase Xylitol dehydrogenase
A0A8I6A2A0	L-iditol 2-dehydrogenase Polyol dehydrogenase Xylitol dehydrogenase
P27867	L-iditol 2-dehydrogenase Polyol dehydrogenase Xylitol dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
L-xylitol catabolic process	IEA ISO
response to cadmium ion	IDA	10620479
sorbitol catabolic process	IBA IEA ISO
response to xenobiotic stimulus	IEP	15064821
response to copper ion	IDA	11044632

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process

sorbitol catabolic process

hexitol catabolic process [inference]

sorbitol catabolic process

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

L-xylitol catabolic process

L-xylitol metabolic process

L-xylitol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

sorbitol catabolic process

pentitol catabolic process [inference]

L-xylitol catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone

response to inorganic substance [inference]

response to metal ion [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
motile cilium	IEA ISO ISS
cytosol	IEA ISO
mitochondrial membrane	IEA
membrane	ISO
mitochondrion	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

organelle membrane [inference]

mitochondrial membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
D-sorbitol dehydrogenase (acceptor) activity	IEA ISO
zinc ion binding	IDA IEA ISO	11306057
NAD binding	IEA ISO
D-xylulose reductase activity	IEA ISO
L-iditol 2-dehydrogenase activity	IBA IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hexitol dehydrogenase activity [inference]

D-xylulose reductase activity

D-sorbitol dehydrogenase (acceptor) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0081376	obsolete sorbitol dehydrogenase deficiency with peripheral neuropathy	Alliance of Genome Resources
DOID:0081427	autosomal recessive distal hereditary motor neuronopathy 8	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:9743	diabetic neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179404	WB:WBGene00011004
Caenorhabditis elegans	179405	WB:WBGene00011003
Drosophila melanogaster	40836	FB:FBgn0024289
Drosophila melanogaster	41313	FB:FBgn0022359
Ciona intestinalis	100184593		CIOIN04253
Callorhinchus milii	103188841		CALMI04292
Latimeria chalumnae	102345933		LATCH13849
Danio rerio	570613	ZFIN:ZDB-GENE-040426-1231	DANRE40437
Astyanax mexicanus	103041581		ASTMX14704
Ictalurus punctatus	100528674		ICTPU22120

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Acknowledgements