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secreted protein acidic and cysteine rich

Summary

Gene Symbol

Sparc

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24791

PubChem

24791

Alliance of Genome Resources

RGD:3742

Annotation

Keyword

Basement membrane
Calcium
Copper
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P16975	Basement-membrane protein 40 Osteonectin Secreted protein acidic and rich in cysteine
A6HEL9	Osteonectin Secreted protein acidic and rich in cysteine

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
ossification	IEP	12365801
negative regulation of endothelial cell proliferation	ISO
negative regulation of endothelial cell proliferation	IEA
heart development	IEP	8287436
response to gravity	IEP	17384275

GO Hierarchy

biological process

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

semicircular canal morphogenesis

embryonic morphogenesis [inference]

semicircular canal morphogenesis

anatomical structure development [inference]

animal organ development [inference]

inner ear development

pigmentation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to L-ascorbic acid

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to abiotic stimulus [inference]

response to gravity

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to L-ascorbic acid

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to L-ascorbic acid

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to cytokine

response to organophosphorus [inference]

response to cAMP

response to calcium ion

response to alcohol [inference]

response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to alcohol [inference]

response to ethanol

response to peptide [inference]

response to peptide hormone

response to salt [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

regulation of cell population proliferation

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
basement membrane	IEA
extracellular space	ISO
extracellular space	IDA	18758911 2322281
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

platelet alpha granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

platelet alpha granule membrane

nuclear matrix

cell junction [inference]

synapse

glutamatergic synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix [inference]

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

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GO Term	Evidence Code	PMID
calcium ion binding	ISO
calcium ion binding	IDA	2322281
calcium ion binding	IBA
calcium ion binding	IEA
collagen binding	ISO

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kazal-type inhibitor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Kazal domain superfamily
Kazal domain

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
vesicle	PMID:18758911
extracellular space	PMID:18758911 PMID:2322281

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6678	Xenbase:XB-GENE-1009630	HUMAN81831
Drosophila melanogaster	8404	FB:FBgn0026562
Drosophila melanogaster	13602	FB:FBgn0026562
Mus musculus	20692	Xenbase:XB-GENE-1009630	MOUSE05866
Xenopus tropicalis	24791	Xenbase:XB-GENE-1009630
Drosophila melanogaster	25434	FB:FBgn0026562
Xenopus tropicalis	176931	Xenbase:XB-GENE-1009630
Bos taurus	282077		BOVIN33790
Danio rerio	321357		DANRE07748
Takifugu rubripes	445895		TAKRU09626