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arachidonate 15-lipoxygenase type B

Summary

Gene Symbol

ALOX15B

Aliases

15-LOX-2

Organism

Homo sapiens (human)

External Links

NCBI Gene

247

HGNC

434

KEGG Gene ID

hsa:247

PubChem

247

Alliance of Genome Resources

HGNC:434

JoGo

ALOX15B

TogoVar

ALOX15B

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell junction
Cell membrane
Cytoskeleton
Dioxygenase
Iron
Lipid metabolism
Lipid-binding
Metal-binding
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O15296	15-lipoxygenase 2 Arachidonate 15-lipoxygenase B Arachidonate 15-lipoxygenase type II Linoleate 13-lipoxygenase 15-LOb

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 30 in total

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GO Term	Evidence Code	PMID
arachidonate metabolic process	IEA
lipoxygenase pathway	IBA
lipoxygenase pathway	IEA
negative regulation of cell migration	TAS
prostate gland development	NAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

cannabinoid signaling pathway [inference]

endocannabinoid signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

cannabinoid biosynthetic process

primary metabolic process [inference]

lipid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

phospholipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipid modification [inference]

lipid oxidation

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

small molecule metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

olefinic compound metabolic process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

prostate gland development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

prostate gland development

anatomical structure development [inference]

reproductive structure development [inference]

prostate gland development

animal gross anatomical part developmental process [inference]

animal organ development [inference]

gland development [inference]

prostate gland development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of growth [inference]

negative regulation of growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of keratinocyte differentiation

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of growth

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

cannabinoid signaling pathway [inference]

endocannabinoid signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell cycle [inference]

negative regulation of cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	IDA
nucleus	IEA
cytosol	TAS
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
iron ion binding	IDA
iron ion binding	IEA
calcium ion binding	IDA
protein binding	IPI
lipid binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K08022

Name

arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) [EC:1.13.11.33 1.13.11.-]

References

12432923

Rhea

RHEA:16869

O₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Enzyme

1.13.11.33

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001233
Gene Name: arachidonate 15-lipoxygenase, type B

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements