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arachidonate 15-lipoxygenase type B

Summary

Gene Symbol

ALOX15B

Aliases

15-LOX-2

Organism

Homo sapiens (human)

External Links

NCBI Gene

247

HGNC

434

KEGG Gene ID

hsa:247

PubChem

247

Alliance of Genome Resources

HGNC:434

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell junction
Cell membrane
Cytoskeleton
Dioxygenase
Iron
Lipid metabolism
Lipid-binding
Metal-binding
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O15296	15-lipoxygenase 2 Arachidonate 15-lipoxygenase B Arachidonate 15-lipoxygenase type II Linoleate 13-lipoxygenase 15-LOb

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
endocannabinoid signaling pathway	IDA	11956198
negative regulation of cell cycle	IDA	11839751
lipid metabolic process	IDA TAS	11839751 17493578 18311922
negative regulation of cell migration		11839751
lipoxin A4 biosynthetic process	IDA	27145229

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

lipoxin A4 biosynthetic process

cannabinoid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

phospholipid metabolic process

lipid modification [inference]

lipid oxidation

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

phospholipid metabolic process

lipid modification [inference]

lipid oxidation

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin metabolic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

phospholipid metabolic process

lipid modification [inference]

lipid oxidation

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin metabolic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process

olefinic compound metabolic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

lipoxin A4 biosynthetic process

cannabinoid biosynthetic process

organic hydroxy compound metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

cannabinoid signaling pathway [inference]

endocannabinoid signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

long-chain fatty acid biosynthetic process [inference]

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 biosynthetic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

phospholipid metabolic process

lipid modification [inference]

lipid oxidation

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

prostate gland development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

prostate gland development

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

prostate gland development

reproductive structure development [inference]

prostate gland development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of growth [inference]

negative regulation of growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of keratinocyte differentiation

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of growth

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

cannabinoid signaling pathway [inference]

endocannabinoid signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of peroxisome proliferator activated receptor signaling pathway [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell cycle [inference]

negative regulation of cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

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GO Term	Evidence Code	PMID
nucleus	IEA
adherens junction	IDA	12704195
cytoskeleton	IDA	12704195
cytosol	IDA TAS	10542053 12704195
plasma membrane	IDA	12704195 27435673

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
arachidonate 15-lipoxygenase activity	IBA IDA	10542053 10625675 11956198 17493578 18311922 24282679 24497644 27145229 27435673 9177185
linoleate 13S-lipoxygenase activity	IDA	10542053
lipid binding	IEA
iron ion binding	IDA	24497644
calcium ion binding	IDA	24497644

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K08022

Name

arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) [EC:1.13.11.33 1.13.11.-]

References

12432923

Rhea

RHEA:16869

O₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Enzyme

1.13.11.33

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:1325	bronchus cancer	DisGeNET
DOID:13739	nutmeg liver	DisGeNET
DOID:14693	Clouston syndrome	DisGeNET
DOID:1612	breast cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1837	diabetic ketoacidosis	DisGeNET
DOID:1936	atherosclerosis	DisGeNET DisGeNET DisGeNET DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET DisGeNET
DOID:2526	prostate adenocarcinoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001233
Gene Name: arachidonate 15-lipoxygenase, type B

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ciona intestinalis	100179479		CIOIN02039
Danio rerio	767741	ZFIN:ZDB-GENE-061013-229
Electrophorus electricus	113590746		ELEEL45274
Esox lucius	105020997		ESOLU70894
Esox lucius	105021020		ESOLU70900
Salmo salar	100194745		SALSA41200
Salmo salar	106593018		SALSA41200
Salmo salar	106602268		SALSA24468
Salmo trutta	115191717		SALTR28314
Salmo trutta	115191719		SALTR28343

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements