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synaptophysin

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24804

PubChem

24804

Alliance of Genome Resources

RGD:3802

Annotation

Keyword

Calcium
Cytoplasmic vesicle
Direct protein sequencing
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Synaptosome
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KP94
P07825	Major synaptic vesicle protein p38

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
regulation of neuronal synaptic plasticity	IBA NAS	12363201
modulation of chemical synaptic transmission	ISO
synaptic vesicle endocytosis	ISO
regulation of synaptic vesicle priming	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

response to amyloid-beta

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
postsynaptic density	IDA	26595655
presynapse	ISO
terminal bouton	HDA IDA IEA ISO	12181340 24876496
protein-containing complex	IDA	8567678
neuron projection terminus	IDA ISO	11786535

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

postsynaptic specialization [inference]

postsynaptic density

neuron projection terminus

axon terminus [inference]

vestibular calyx terminal

presynapse

terminal bouton

axon terminus [inference]

vestibular calyx terminal

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11786535 17005904 18662323 29476059
protein-containing complex binding	IPI	8567678
SNARE binding	IPI	19196426
syntaxin-1 binding	IDA	7553862
identical protein binding	IEA ISO

GO Hierarchy

syntaxin binding [inference]

syntaxin-1 binding

protein domain specific binding

SH2 domain binding

identical protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

protein-containing complex binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

synaptophysin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
regulation of neuronal synaptic plasticity

Displaying **all 2** entries
InterPro
Marvel domain
Synaptophysin/synaptoporin

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
protein-containing complex	PMID:8567678
neuron projection terminus	PMID:11786535

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0112035	non-syndromic X-linked intellectual disability 96	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 48 in total

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Species	Gene ID	OrthoDB
Castor canadensis	109691529	51338_0:0027ab
Mus caroli	110286857	10089_0:004df9
Mus pahari	110313502	10093_0:004d2d
Meriones unguiculatus	110561914	10047_0:003a93
Urocitellus parryii	113195250	9999_0:0032b5
Marmota flaviventris	114105717	93162_0:004683
Grammomys surdaster	114624084	491861_0:00181f
Peromyscus leucopus	114701285	10041_0:00491b
Mastomys coucha	116102566	35658_0:00020b
Rattus rattus	116888361	10117_0:005134

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements