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synaptophysin

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24804

PubChem

24804

Alliance of Genome Resources

RGD:3802

Annotation

Keyword

Calcium
Cytoplasmic vesicle
Direct protein sequencing
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Synaptosome
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KP94
P07825	Major synaptic vesicle protein p38

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
regulation of long-term neuronal synaptic plasticity	IEA ISO
endocytosis	IMP	17005904
response to amyloid-beta	IEP	20847448
regulation of short-term neuronal synaptic plasticity	IEA ISO
regulation of opioid receptor signaling pathway	IDA	17005904

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

response to amyloid-beta

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of opioid receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IBA IDA IEA ISO	23792689 3923488
Schaffer collateral - CA1 synapse	IEA ISO
neuron spine	IDA	20083202
membrane	ISO
basal part of cell	ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

postsynaptic specialization [inference]

postsynaptic density

neuron projection terminus

axon terminus [inference]

vestibular calyx terminal

presynapse

terminal bouton

axon terminus [inference]

vestibular calyx terminal

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11786535 17005904 18662323 29476059
protein-containing complex binding	IPI	8567678
SNARE binding	IPI	19196426
syntaxin-1 binding	IDA	7553862
identical protein binding	IEA ISO

GO Hierarchy

syntaxin binding [inference]

syntaxin-1 binding

protein domain specific binding

SH2 domain binding

identical protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

protein-containing complex binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

synaptophysin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
regulation of neuronal synaptic plasticity

Displaying **all 2** entries
InterPro
Marvel domain
Synaptophysin/synaptoporin

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
protein-containing complex	PMID:8567678
neuron projection terminus	PMID:11786535

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0112035	non-syndromic X-linked intellectual disability 96	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 48** of 48 in total

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Species	Gene ID	OrthoDB
Microtus fortis	126512924	100897_0:0031b5
Acomys russatus	127185759	60746_0:004e96
Phodopus roborovskii	127218366	109678_0:00118b
Apodemus sylvaticus	127675080	10129_0:005513
Peromyscus californicus insignis	128117793	564181_0:00026b
Psammomys obesus	129669364	48139_1:004ca5
Chionomys nivalis	130867469	269649_0:00533e
Peromyscus eremicus	131899679	42410_0:00526f

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements