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synaptotagmin 2

Summary

Gene Symbol

Syt2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24805

PubChem

24805

Alliance of Genome Resources

RGD:3804

Annotation

Keyword

3D-structure
Calcium
Cytoplasm
Cytoplasmic vesicle
Differentiation
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P29101	Synaptotagmin II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
synaptic vesicle exocytosis	TAS	1856191
vesicle-mediated transport	IBA
regulation of calcium ion-dependent exocytosis	IBA
cell differentiation	IEA
synaptic vesicle endocytosis

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular developmental process [inference]

cell differentiation

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

developmental process [inference]

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

establishment of localization in cell [inference]

synaptic vesicle exocytosis

calcium ion-regulated exocytosis of neurotransmitter

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

positive regulation of transport [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of transport [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle membrane organization [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

positive regulation of synaptic vesicle membrane organization [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of vesicle fusion [inference]

positive regulation of vesicle fusion [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

positive regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

calcium-dependent activation of synaptic vesicle fusion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
axon	ISO
axon	IBA
synaptic vesicle membrane	TAS	1856191

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane [inference]

chromaffin granule membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

exocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

exocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

exocytic vesicle

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
SNARE binding	IBA
phosphatidylserine binding	ISO
calcium ion binding	ISO
calcium ion binding	TAS	1856191
calcium ion binding	IEA

GO Hierarchy

syntaxin binding

clathrin binding

lipid binding [inference]

phospholipid binding [inference]

small molecule binding [inference]

alcohol binding [inference]

inositol 1,3,4,5 tetrakisphosphate binding

ion binding [inference]

anion binding [inference]

inositol 1,3,4,5 tetrakisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

modified amino acid binding [inference]

phosphatidylserine binding

small molecule sensor activity [inference]

metal ion sensor activity [inference]

calcium ion sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

synaptotagmin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
calcium ion binding
calcium ion-regulated exocytosis of neurotransmitter
calcium-dependent phospholipid binding
cellular response to calcium ion
clathrin binding
metal ion binding
phosphatidylserine binding
regulation of calcium ion-dependent exocytosis
regulation of dopamine secretion

Displaying **all 3** entries
InterPro
C2 domain superfamily
C2 domain
Synaptotagmin

Ortholog

Displaying entries **21 - 30** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Cavia porcellus	100729470	CAVPO07406
Cricetulus griseus	100761723	CRIGR05335
Sarcophilus harrisii	100920304	SARHA06550
Otolemur garnettii	100959547	OTOGA09984
Pan paniscus	100970593	PANPA03483
Papio anubis	101008797	PAPAN21784
Saimiri boliviensis boliviensis	101053680	SAIBB29838
Takifugu rubripes	101076615	TAKRU21201
Felis catus	101099015	FELCA37494
Tursiops truncatus	101323262	TURTR11505

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UniCarb-DR

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OrthoDB (Group)

International Collaboration

Acknowledgements