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transthyretin

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24856

PubChem

24856

Alliance of Genome Resources

RGD:3916

Annotation

Keyword

3D-structure
Direct protein sequencing
Gamma-carboxyglutamic acid
Glycoprotein
Phosphoprotein
Reference proteome
Secreted
Signal
Sulfation
Thyroid hormone
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P02767	Prealbumin TBPA
A6J2G2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
retinoid metabolic process	ISO
retinoid metabolic process	IEA
negative regulation of glomerular filtration	ISO
negative regulation of glomerular filtration	IEA
purine nucleobase metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

hormone metabolic process [inference]

thyroid hormone metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

cellular process [inference]

signal transduction

phototransduction [inference]

phototransduction, visible light

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renal system process involved in regulation of blood volume [inference]

regulation of glomerular filtration [inference]

negative regulation of glomerular filtration

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

regulation of cellular process [inference]

signal transduction

phototransduction [inference]

phototransduction, visible light

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of renal system process [inference]

regulation of glomerular filtration [inference]

negative regulation of glomerular filtration

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IEA
extracellular space	ISO
extracellular space	IDA	11995998
extracellular space	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
hormone activity	IEA
small molecule binding	ISO
hormone binding	IDA	11995998
identical protein binding	ISO
identical protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

hormone activity

identical protein binding

small molecule binding

hormone binding

thyroid hormone binding

protein-containing complex binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transthyretin

Functional Category

F: Nucleotide transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
hormone activity
purine nucleobase metabolic process
thyroid hormone binding

Displaying **all 5** entries
InterPro
Transthyretin, conserved site
Transthyretin, thyroxine binding site
Transthyretin/hydroxyisourate hydrolase domain superfamily
Transthyretin/hydroxyisourate hydrolase domain
Transthyretin/hydroxyisourate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
extracellular space	PMID:11995998
protein-containing complex	PMID:9260907

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7276	Xenbase:XB-GENE-479395	HUMAN38013
Mus musculus	22139	Xenbase:XB-GENE-479395	MOUSE23221
Xenopus tropicalis	24856	Xenbase:XB-GENE-479395
Bos taurus	280948		BOVIN19493
Sus scrofa	397419		PIGXX29930
Xenopus tropicalis	397787	Xenbase:XB-GENE-479395
Ovis aries	443389		SHEEP11836
Danio rerio	449556		DANRE19928
Canis lupus familiaris	480167		CANLF17554
Pan troglodytes	493188		PANTR16085