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ferritin heavy chain 1

Summary

Gene Symbol

FTH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2495

PubChem

2495

Alliance of Genome Resources

HGNC:3976

JoGo

FTH1

TogoVar

FTH1

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Cytoplasmic vesicle
Iron storage
Lysosome
Metal-binding
Neurodegeneration
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P02794	Cell proliferation-inducing gene 15 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
iron ion transport	IBA
intracellular iron ion homeostasis	IEA
intracellular sequestering of iron ion
immune response	ISS
negative regulation of cell population proliferation	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

maintenance of location in cell [inference]

sequestering of iron ion [inference]

intracellular sequestering of iron ion

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

response to stimulus [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

maintenance of location [inference]

sequestering of metal ion [inference]

sequestering of iron ion [inference]

intracellular sequestering of iron ion

maintenance of location in cell [inference]

sequestering of iron ion [inference]

intracellular sequestering of iron ion

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

regulation of fibroblast proliferation [inference]

negative regulation of fibroblast proliferation

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
nucleus	HDA	21630459
cytoplasm	IBA
autophagosome	IEA
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

ferritin complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

secondary lysosome [inference]

autolysosome

autophagosome

autolysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

secondary lysosome [inference]

autolysosome

autophagosome

autolysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
ferric iron binding	IBA
identical protein binding	IPI	25416956 31515488 33087927
iron ion sequestering activity	IDA	9924025

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor [inference]

ferroxidase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

sulfur compound binding [inference]

ferric iron binding

molecular sequestering activity [inference]

metal ion sequestering activity [inference]

iron ion sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110734	neurodegeneration with brain iron accumulation	Alliance of Genome Resources
DOID:0111031	hemochromatosis type 5	Alliance of Genome Resources

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