GlyCosmos Portal

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	IDA	33381
tyrosine 3-monooxygenase activity	ISO
tyrosine 3-monooxygenase activity	IDA	19489646 20025246 20412389
tyrosine 3-monooxygenase activity	IBA
tyrosine 3-monooxygenase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tyrosine 3-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tyrosine 3-monooxygenase activity

binding [inference]

protein binding

small molecule binding

oxygen binding

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding

cation binding [inference]

dopamine binding

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrahydrobiopterin binding

catecholamine binding [inference]

dopamine binding

sulfur compound binding [inference]

ferric iron binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tryptophan 5-hydroxylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
aromatic amino acid metabolic process
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
oxidoreductase activity

Displaying **all 6** entries
InterPro
ACT domain
ACT-like domain
Aromatic amino acid hydroxylase superfamily
Aromatic amino acid hydroxylase, C-terminal
Aromatic amino acid hydroxylase
Aromatic amino acid monoxygenase, C-terminal domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
synaptic vesicle	PMID:15496595 PMID:19903816
terminal bouton	PMID:14681933
dendrite	PMID:21362438
axon	PMID:14681933
perikaryon	PMID:20434498
neuronal cell body	PMID:21325515

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14330	Parkinson's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7054		HUMAN03918
Mus musculus	21823	Xenbase:XB-GENE-992305	MOUSE57235
Xenopus tropicalis	25085	Xenbase:XB-GENE-992305
Danio rerio	30384		DANRE27892
Bos taurus	280707		BOVIN23696
Canis lupus familiaris	403444		CANLF05922
Pan troglodytes	450955		PANTR02018
Macaca mulatta	721137		MACMU09925
Meleagris gallopavo	723977		MELGA10631
Equus caballus	100146648		HORSE05974

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements