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MIRAGE

5-hydroxytryptamine receptor 2C

Summary

Gene Symbol

Htr2c

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25187

PubChem

25187

Alliance of Genome Resources

RGD:2848

Annotation

Keyword

3D-structure
Behavior
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q62842
P08909	5-hydroxytryptamine receptor 1C Serotonin receptor 2C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 40 in total

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GO Term	Evidence Code	PMID
serotonin receptor signaling pathway	IBA
chemical synaptic transmission	IBA
locomotory behavior	IEA
feeding behavior	ISO
feeding behavior	IMP	15705738

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

phospholipase D-activating G protein-coupled receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

serotonin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

nonassociative learning [inference]

sensitization

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning [inference]

nonassociative learning [inference]

sensitization

adult behavior [inference]

behavioral response to nicotine

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of gamma-aminobutyric acid secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of amine transport [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

phospholipase D-activating G protein-coupled receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

serotonin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of calcium-mediated signaling

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of phosphatidylinositol biosynthetic process

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of corticotropin-releasing hormone secretion

regulation of appetite

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
external side of plasma membrane	IDA	1373499

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

G protein-coupled serotonin receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
Gq/11-coupled serotonin receptor activity	ISS
Gq/11-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	IMP	15663485
G protein-coupled serotonin receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

organic cyclic compound binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gq/11-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hydrolase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
S-formylglutathione hydrolase activity
formaldehyde catabolic process
hydrolase activity, acting on ester bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Alpha/Beta hydrolase fold
Esterase-like
S-formylglutathione hydrolase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cell surface	PMID:15663485

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:1470	major depressive disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:2030	anxiety disorder	Alliance of Genome Resources
DOID:303	substance-related disorder	Alliance of Genome Resources
DOID:809	cocaine abuse	Alliance of Genome Resources
DOID:9975	cocaine dependence	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 49 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Octodon degus	101580134		OCTDE17182
Jaculus jaculus	101605418		JACJA10555
Mustela putorius furo	101670625		MUSPF02676
Ictidomys tridecemlineatus	101976815		ICTTR04050
Chinchilla lanigera	102027753		CHILA19333
Macaca fascicularis	102120602		MACFA44972
Capra hircus	102188025		CAPHI31323
Chlorocebus sabaeus	103232513		CHLSB18748
Carlito syrichta	103265332		CARSF19506
Ursus maritimus	103679732		URSMA24127

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025