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alpha-L-fucosidase 2

Summary

Gene Symbol

FUCA2

Aliases

MGC1314
a-L-fucosidase 2
dJ20N2.5
plasma fucosidase
α-L-fucosidase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2519

HGNC

4008

KEGG Gene ID

hsa:2519

PubChem

2519

Alliance of Genome Resources

HGNC:4008

Annotation

Keyword

Alternative splicing
Glycoprotein
Glycosidase
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BTY2	Alpha-L-fucoside fucohydrolase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
fucose metabolic process	IDA	19666478
fucose metabolic process	IBA
response to bacterium	IMP	19666478
glycoside catabolic process	IDA	19666478
glycoside catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

glycoside catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organic substance catabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of entry of bacterium into host cell

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	19666478
lysosome	IBA
endoplasmic reticulum lumen	TAS
azurophil granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-L-fucosidase activity	IDA	19666478
alpha-L-fucosidase activity	IBA
protein binding	IPI	25416956 31515488 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

fucosidase activity [inference]

alpha-L-fucosidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha L fucosidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
alpha-L-fucosidase activity
fucose metabolic process
fucosidase activity
hydrolase activity

Displaying **all 3** entries
InterPro
Alpha-L-fucosidase, metazoa-type
Glycoside hydrolase superfamily
Glycoside hydrolase, family 29

KEGG BRITE Database

Orthology

K01206

Name

alpha-L-fucosidase [EC:3.2.1.51]

References

Rhea

RHEA:12288

H₂O + an α-L-fucoside

L-fucose + an alcohol

Enzyme

3.2.1.51

PMID

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	2517	FB:FBgn0285958
Xenopus tropicalis	2519	Xenbase:XB-GENE-945131
Drosophila melanogaster	24375	FB:FBgn0285958
Mus musculus	66848	Xenbase:XB-GENE-945131	MOUSE01971
Drosophila melanogaster	71665	FB:FBgn0285958
Xenopus tropicalis	189173	Xenbase:XB-GENE-945131
Xenopus tropicalis	292485	Xenbase:XB-GENE-945131
Danio rerio	445487		DANRE11941
Pan troglodytes	463039		PANTR39222
Bos taurus	515729		BOVIN35913

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements