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ST6 beta-galactoside alpha-2,6-sialyltransferase 1

Summary

Gene Symbol

St6gal1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25197

KEGG Gene ID

rno:25197

PubChem

25197

Alliance of Genome Resources

RGD:3676

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Phosphoprotein
Proteomics identification
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F2Z3S3
P13721	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 ST6Gal I Sialyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
N-acetylneuraminate metabolic process	ISS
N-acetylneuraminate metabolic process	ISO
protein glycosylation	ISO
protein glycosylation	IEA
protein N-linked glycosylation via asparagine	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein sialylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein sialylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein sialylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein sialylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

sialylation

protein sialylation

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein sialylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of substrate adhesion-dependent cell spreading

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of leukocyte apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

regulation of macrophage apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of myeloid cell apoptotic process [inference]

negative regulation of macrophage apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of macrophage apoptotic process

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GO Term	Evidence Code	PMID
Golgi trans cisterna	IDA	12626411
Golgi membrane	ISO
extracellular region	IEA
Golgi apparatus	IBA
Golgi medial cisterna	IDA	12626411

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
beta-galactoside alpha-2,6-sialyltransferase activity	ISS
beta-galactoside alpha-2,6-sialyltransferase activity	ISO
beta-galactoside alpha-2,6-sialyltransferase activity	IBA
sialyltransferase activity	ISO
sialyltransferase activity	IDA	12626411

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-galactoside alpha-2,6-sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
beta-galactoside alpha-2,6-sialyltransferase activity
sialylation
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

KEGG BRITE Database

Orthology

K00778

Name

beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.3.1]

References

2408023

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05990	2.4.3.1	G78059CC	G56749GV

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
Golgi trans cisterna	PMID:12626411
Golgi medial cisterna	PMID:12626411

Rhea

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP

Enzyme

2.4.3.1

PMID

2460092

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.1

PMID

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate

H⁺ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP

Enzyme

2.4.3.1

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3070	high grade glioma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012479
Gene Name: ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6480	Xenbase:XB-GENE-983202	HUMAN73942
Mus musculus	20440	Xenbase:XB-GENE-983202	MOUSE19129
Xenopus tropicalis	25197	Xenbase:XB-GENE-983202
Xenopus tropicalis	37950	Xenbase:XB-GENE-983202
Drosophila melanogaster	84620	FB:FBgn0035050
Drosophila melanogaster	240119	FB:FBgn0035050
Bos taurus	282073		BOVIN14810
Drosophila melanogaster	301155	FB:FBgn0035050
Drosophila melanogaster	403116	FB:FBgn0035050
Drosophila melanogaster	407846	FB:FBgn0035050

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UniCarb-DR

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Other Information

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements