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Guidelines
MIRAGE
proprotein convertase subtilisin/kexin type 1

Summary
Gene Symbol
  • Pcsk1
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
25204
PubChem
25204
Alliance of Genome Resources
Annotation
Keyword
  • Calcium
  • Cleavage on pair of basic residues
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Reference proteome
  • Serine protease
  • Signal
  • Zymogen
Proteins
Displaying all 2 entries
UniProt Protein Name
A6I4E7
  • Prohormone convertase 1
  • Proprotein convertase 1
P28840
  • Prohormone convertase 1
  • Proprotein convertase 1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 11 - 15 of 27 in total
GO Term Evidence Code PMID
protein autoprocessing
pituitary gland development
neurogenesis
insulin processing
pancreas development
GO Hierarchy
Displaying entries 11 - 15 of 15 in total
GO Term Evidence Code PMID
neuron projection
neuronal cell body
perikaryon
axon terminus
perinuclear region of cytoplasm
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Neuroendocrine convertase 1
Functional Category
  • L: Replication, recombination and repair
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying all 5 entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity
Displaying entries 1 - 10 of 12 in total
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, pro-domain superfamily
Peptidase S8, pro-domain
Peptidase S8, subtilisin, Asp-active site
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Alliance of Genome Resources
Expression
Displaying all 8 entries
Location References
Disease
Disease Ontology
Displaying all 2 entries
DO ID Disease Name Source
DOID:4195 hyperglycemia
DOID:9352 type 2 diabetes mellitus
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026