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cartilage oligomeric matrix protein

Summary

Gene Symbol

Comp

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25304

PubChem

25304

Alliance of Genome Resources

RGD:2378

Annotation

Keyword

3D-structure
Apoptosis
Calcium
Cell adhesion
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Heparin-binding
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P35444

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 37 in total

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GO Term	Evidence Code	PMID
regulation of gene expression	IEA ISO
negative regulation of apoptotic process	IEA ISO
chondrocyte development	IEA ISO
limb development	IEA ISO
growth plate cartilage development	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular metabolic process [inference]

cellular senescence

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

chondrocyte proliferation

cellular metabolic process [inference]

cellular senescence

cellular developmental process [inference]

cell development [inference]

chondrocyte development

muscle cell development

vascular associated smooth muscle cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

export from cell [inference]

secretion by cell [inference]

protein secretion

multicellular organismal process [inference]

ossification

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

nervous system process [inference]

neuromuscular process

musculoskeletal movement

multicellular organism growth

organ growth [inference]

bone growth

endochondral bone growth

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

coagulation [inference]

blood coagulation

multicellular organismal movement [inference]

musculoskeletal movement

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

bone morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

connective tissue development [inference]

cell development [inference]

chondrocyte development

muscle cell development

vascular associated smooth muscle cell development

animal organ development [inference]

skin development

cartilage development

cartilage development involved in endochondral bone morphogenesis [inference]

growth plate cartilage development

system development [inference]

skeletal system development

appendage development [inference]

limb development

cellular developmental process [inference]

cell development [inference]

chondrocyte development

muscle cell development

vascular associated smooth muscle cell development

growth [inference]

developmental growth [inference]

multicellular organism growth

organ growth [inference]

bone growth

endochondral bone growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

organic substance transport [inference]

protein transport [inference]

protein secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of hemostasis

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of hemostasis [inference]

negative regulation of hemostasis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

negative regulation of hemostasis

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular matrix	IEA ISO
protein-containing complex	IEA ISO
collagen-containing extracellular matrix	IBA IDA	16778685
extracellular region	IEA ISO ISS
extracellular space	IEA ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
protease binding	IEA ISO
vitamin D binding	IMP	12426368
collagen binding	IEA ISO
BMP binding	IEA ISO
fibronectin binding	IDA	12225811

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

fibronectin binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

cytokine binding [inference]

BMP binding

proteoglycan binding

heparan sulfate proteoglycan binding

cell adhesion molecule binding [inference]

integrin binding

lipid binding [inference]

steroid binding [inference]

vitamin D binding

small molecule binding [inference]

vitamin binding [inference]

vitamin D binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

organic cyclic compound binding [inference]

steroid binding [inference]

vitamin D binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cartilage oligomeric matrix protein

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
X: Mobilome: prophages, transposons

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying entries **1 - 10** of 12 in total

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InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
NOTCH1 EGF-like calcium-binding domain
TSP type-3 repeat
Thrombospondin, C-terminal
Thrombospondin, type 3 repeat
Thrombospondin, type 3-like repeat
Thrombospondin-5, coiled coil domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
collagen-containing extracellular matrix	PMID:16778685

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0070303	multiple epiphyseal dysplasia 1	Alliance of Genome Resources
DOID:0070467	carpal tunnel syndrome 2	Alliance of Genome Resources
DOID:0080047	pseudoachondroplasia	Alliance of Genome Resources
DOID:12721	multiple epiphyseal dysplasia	Alliance of Genome Resources
DOID:2256	osteochondrodysplasia	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 89 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ciona intestinalis	100169670			CIOIN08718
Ciona intestinalis	100169671			CIOIN06819
Taeniopygia guttata	100218446			TAEGU16195
Danio rerio	100318854		ZFIN:ZDB-GENE-060606-1
Callithrix jacchus	100391690			CALJA22669
Pongo abelii	100447159			PONAB15888
Ailuropoda melanoleuca	100479895			AILME19298
Xenopus tropicalis	100494714		Xenbase:XB-GENE-994160
Meleagris gallopavo	100548314			MELGA09556
Cavia porcellus	100720040	10141_0:00132e		CAVPO19834

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements