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Guidelines

MIRAGE

cystatin C

Summary

Gene Symbol

Cst3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25307

PubChem

25307

Alliance of Genome Resources

RGD:2432

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Thiol protease inhibitor

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6K7D9
P14841	Cystatin-3
A6K7E1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **26 - 27** of 27 in total

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GO Term	Evidence Code	PMID
cellular response to hydrogen peroxide	IEP	17440810
supramolecular fiber organization	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

Sertoli cell development

embryo implantation

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

Sertoli cell development

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

animal organ development [inference]

sensory organ development [inference]

eye development

gonad development [inference]

male gonad development

gland development [inference]

salivary gland development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to wounding [inference]

response to axon injury

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate

response to organic cyclic compound

response to estradiol

response to lipid [inference]

response to estradiol

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of collagen catabolic process [inference]

negative regulation of collagen catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

negative regulation of developmental process [inference]

negative regulation of blood vessel remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of blood vessel remodeling [inference]

negative regulation of blood vessel remodeling

negative regulation of developmental process [inference]

negative regulation of blood vessel remodeling

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of multicellular organismal process [inference]

regulation of tissue remodeling

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of blood vessel remodeling [inference]

negative regulation of blood vessel remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
basement membrane	IDA	15872057
extracellular space	ISO
extracellular space	IDA	2689174
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular non-membrane-bounded organelle [inference]

contractile fiber

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	ISO
protease binding	ISO
protease binding	IDA	2622871 8761177
endopeptidase inhibitor activity	ISO
cysteine-type endopeptidase inhibitor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

identical protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cystatin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Cystatin domain
Cystatin superfamily

Alliance of Genome Resources

Expression

Displaying **all 10** entries
Location	References
vesicle	PMID:10950881
contractile muscle fiber	PMID:8245434
basement membrane	PMID:15872057
extracellular space	PMID:2689174
neuronal cell body	PMID:14738488
nuclear membrane	PMID:15872057
axon	PMID:14738488
cell projection	PMID:16309830
multivesicular body	PMID:10950881
perinuclear region of cytoplasm	PMID:16414118

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026