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atypical chemokine receptor 1 (Duffy blood group)

Summary

Gene Symbol

ACKR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2532

PubChem

2532

Alliance of Genome Resources

HGNC:4035

Annotation

Keyword

3D-structure
Alternative splicing
Blood group antigen
Direct protein sequencing
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q5Y7A1	Duffy antigen/chemokine receptor
Q5Y7A2	Duffy antigen/chemokine receptor
Q16570	Duffy antigen/chemokine receptor Fy glycoprotein Glycoprotein D Plasmodium vivax receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
defense response	NAS	10570183
chemokine-mediated signaling pathway	IEA
regulation of chemokine production	IBA
inflammatory response	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of chemokine production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
recycling endosome	IEA
early endosome	IEA
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18230715 21743458
signaling receptor activity	TAS	7689250
G protein-coupled receptor activity	IEA
C-C chemokine binding	IBA IPI	7517217
transmembrane signaling receptor activity	TAS	9058825

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atypical chemokine receptor 1

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
C-C chemokine binding
chemokine binding
chemokine-mediated signaling pathway
inflammatory response

Displaying 1 entry
InterPro
Duffy antigen/chemokine receptor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12365	malaria	Alliance of Genome Resources
DOID:12978	Plasmodium vivax malaria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13349		MGI:1097689	MOUSE30632
Rattus norvegicus	689105		RGD:1596198	RATNO06534
Macaca mulatta	719284			MACMU24096
Pan troglodytes	745985	9598_0:0001a8		PANTR22692
Monodelphis domestica	100030135			MONDO11032
Equus caballus	100057225			HORSE33823
Sus scrofa	100154447			PIGXX23786
Callithrix jacchus	100398804			CALJA15659
Pongo abelii	100438260	9601_0:000458		PONAB19117
Ailuropoda melanoleuca	100476340			AILME04530

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Annotation

OrthoDB (Group)

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Acknowledgements