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atypical chemokine receptor 1 (Duffy blood group)

Summary

Gene Symbol

ACKR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2532

PubChem

2532

Alliance of Genome Resources

HGNC:4035

Annotation

Keyword

3D-structure
Alternative splicing
Blood group antigen
Direct protein sequencing
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q5Y7A1	Duffy antigen/chemokine receptor
Q5Y7A2	Duffy antigen/chemokine receptor
Q16570	Duffy antigen/chemokine receptor Fy glycoprotein Glycoprotein D Plasmodium vivax receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
defense response	NAS	10570183
inflammatory response	IBA
regulation of chemokine production	IBA
chemokine-mediated signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of chemokine production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
early endosome	IEA
plasma membrane	TAS
recycling endosome	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	TAS	9058825
G protein-coupled receptor activity	IEA
protein binding	IPI	18230715 21743458
C-C chemokine binding	IBA
C-C chemokine binding	IPI	7517217

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Atypical chemokine receptor 1

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
C-C chemokine binding
chemokine binding
chemokine-mediated signaling pathway
inflammatory response

Displaying 1 entry
InterPro
Duffy antigen/chemokine receptor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12365	malaria	Alliance of Genome Resources
DOID:12978	Plasmodium vivax malaria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	2532	RGD:1596198
Mus musculus	13349	MGI:1097689	MOUSE30632
Rattus norvegicus	689105		RATNO06534
Macaca mulatta	719284		MACMU24096
Pan troglodytes	745985		PANTR22692
Monodelphis domestica	100030135		MONDO11032
Equus caballus	100057225		HORSE33823
Sus scrofa	100154447		PIGXX23786
Callithrix jacchus	100398804		CALJA15659
Pongo abelii	100438260		PONAB19117

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements