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MIRAGE
interleukin 10
Summary
- Gene Symbol
-
- Il10
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cytokine
- Disulfide bond
- Glycoprotein
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A7R8C3K4 |
|
| P29456 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of cytokine production | ||
| negative regulation of cytokine production | ||
| positive regulation of cytokine production | ||
| positive regulation of cytokine production | ||
| positive regulation of endothelial cell proliferation |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
negative regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular space | ||
| extracellular space | ||
| extracellular space | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytokine activity | ||
| cytokine activity | ||
| interleukin-10 receptor binding | ||
| interleukin-10 receptor binding | ||
| protein dimerization activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- interleukin-10
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| immune response |
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Interleukin-10, conserved site |
| Interleukin-10/19/20/22/24/26 family |
| Interleukin-10 |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11446 | sciatic neuropathy | |
| DOID:224 | transient cerebral ischemia | |
| DOID:2841 | asthma | |
| DOID:289 | endometriosis | |
| DOID:3602 | toxic encephalopathy | |
| DOID:4780 | anti-basement membrane glomerulonephritis | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:820 | myocarditis | |
| DOID:850 | lung disease | |
| DOID:8677 | perinatal necrotizing enterocolitis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3586 | Xenbase:XB-GENE-479918 | HUMAN54475 | |
| 16153 | Xenbase:XB-GENE-479918 | MOUSE28471 | |
| 25325 | Xenbase:XB-GENE-479918 | ||
| 281246 | BOVIN07927 | ||
| 397106 | PIGXX35950 | ||
| 403628 | CANLF17078 | ||
| 443342 | SHEEP03532 | ||
| 469657 | PANTR23532 | ||
| 493683 | FELCA36265 | ||
| 553957 | DANRE02413 |
