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alpha-1-microglobulin/bikunin precursor

Summary

Gene Symbol

Ambp

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25377

PubChem

25377

Alliance of Genome Resources

RGD:2102

Annotation

Keyword

Cell membrane
Chromophore
Cleavage on pair of basic residues
Cytoplasm
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Extracellular matrix
Mitochondrion inner membrane
Nucleus
Oxidoreductase
Proteoglycan
Proteomics identification
Reference proteome
Repeat
Serine protease inhibitor
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8L2Q3T3
A6J7X0
Q64240

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
negative regulation of peptidase activity
hemoglobin metabolic process	ISS
hemoglobin metabolic process	ISO
protein catabolic process	IDA	11307954
cellular response to reactive oxygen species	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process [inference]

cytochrome c metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular detoxification [inference]

cellular oxidant detoxification

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	ISS
extracellular space	ISO
extracellular space	IDA	11307954
mitochondrial inner membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

nuclear membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

lumenal side of membrane [inference]

matrix side of mitochondrial inner membrane

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	ISS
serine-type endopeptidase inhibitor activity	ISO
serine-type endopeptidase inhibitor activity	IDA	11307954 3263966
serine-type endopeptidase inhibitor activity	IBA
serine-type endopeptidase inhibitor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgA binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

chondroitin sulfate binding

collagen fibril binding

sulfur compound binding [inference]

chondroitin sulfate binding

antioxidant activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-1-microglobulin/bikunin precursor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 7** entries
InterPro
Alpha-1-microglobulin
Calycin
Lipocalin/cytosolic fatty-acid binding domain
Pancreatic trypsin inhibitor Kunitz domain superfamily
Pancreatic trypsin inhibitor Kunitz domain
Protein AMBP
Proteinase inhibitor I2, Kunitz, conserved site