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Sre1 cleavage-activating protein Scap Scp1

Summary

Gene Symbol

scp1

Organism

Schizosaccharomyces pombe (fission yeast)

External Links

NCBI Gene: 2541065
PubChem: 2541065

Annotation

Keyword

3D-structure
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Lipid-binding
Reference proteome
Repeat
Steroid metabolism
Transmembrane helix
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
O43043

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
steroid metabolic process
SREBP signaling pathway	IMP	15797383
regulation of cholesterol biosynthetic process	IBA
positive regulation of ergosterol biosynthetic process	IC
cellular response to hypoxia	TAS	16537923

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

cellular response to hypoxia

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of ergosterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of ergosterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of ergosterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of ergosterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of ergosterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of ergosterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of ergosterol biosynthetic process

regulation of ergosterol biosynthetic process [inference]

positive regulation of ergosterol biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of ergosterol biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS	16537923
endoplasmic reticulum	HDA	16823372
endoplasmic reticulum membrane	IBA
SREBP-SCAP complex	IBA
SREBP-SCAP complex	IPI	15797383

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

SREBP-SCAP complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
sterol binding	IEA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sterol regulatory element-binding protein cleavage-activating protein

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
lipid binding
lipid metabolic process
regulation of cholesterol biosynthetic process
steroid metabolic process

Displaying **all 4** entries
InterPro
Sterol regulatory element-binding protein cleavage-activating protein
Sterol-sensing domain
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily