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DNA endonuclease III

Summary

Gene Symbol

nth1

Organism

Schizosaccharomyces pombe (fission yeast)

External Links

NCBI Gene: 2543510
PubChem: 2543510

Annotation

Keyword

4Fe-4S
DNA repair
Glycosidase
Lyase
Mitochondrion
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q09907	Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
base-excision repair	IDA	8811082
base-excision repair, AP site formation	IDA	17641464
base-excision repair, AP site formation	IMP	12675805
base-excision repair, AP site formation	IBA
nucleotide-excision repair	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IDA	16076563
nucleus	IBA
nucleus	HDA	16823372
mitochondrial matrix	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IDA	8811082 9425081
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IMP	12675805
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IBA
DNA binding	ISM
DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
DNA repair
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair, AP site formation
base-excision repair
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
lyase activity

Displaying **all 6** entries
InterPro
DNA glycosylase
Endonuclease III-like protein 1
Endonuclease III-like, conserved site-2
Helix-hairpin-helix motif
Helix-hairpin-helix, base-excision DNA repair, C-terminal
HhH-GPD domain