GlyCosmos Portal

Submissions

lysophosphatidylcholine acyltransferase 4

Summary

Gene Symbol

LPCAT4

Aliases

FLJ10257
LPAAT-eta
LPEAT2
LPLAT10
lysophosphatidylethanolamine acyltransferase 2
lysophospholipid acyltransferase 10

Organism

Homo sapiens (human)

External Links

NCBI Gene

254531

HGNC

30059

KEGG Gene ID

hsa:254531

PubChem

254531

Alliance of Genome Resources

HGNC:30059

Annotation

Keyword

Acyltransferase
Endoplasmic reticulum
Glycoprotein
Phospholipid biosynthesis
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q643R3	1-acylglycerol-3-phosphate O-acyltransferase 7 1-acylglycerophosphocholine O-acyltransferase 1-acylglycerophosphoserine O-acyltransferase 1-alkenylglycerophosphoethanolamine O-acyltransferase 1-alkylglycerophosphocholine O-acetyltransferase Acyltransferase-like 3 Lysophosphatidylcholine acyltransferase 4 Lysophosphatidylethanolamine acyltransferase 2 Plasmalogen synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
phosphatidylserine acyl-chain remodeling	IDA TAS	18458083
phosphatidylcholine acyl-chain remodeling	IDA TAS	18458083
phosphatidylethanolamine acyl-chain remodeling	IDA TAS	18458083
phosphatidylglycerol acyl-chain remodeling
phosphatidic acid biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol acyl-chain remodeling

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA	18458083
endoplasmic reticulum membrane
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **6 - 9** of 9 in total

« First

‹ Prev

1

2
GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity
1-acylglycerophosphoethanolamine O-acyltransferase activity	IDA	18458083
2-acylglycerol-3-phosphate O-acyltransferase activity
lysophospholipid acyltransferase activity	IDA IMP	18458083

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

O-acetyltransferase activity [inference]

1-alkylglycerophosphocholine O-acetyltransferase activity

acetyltransferase activity [inference]

O-acetyltransferase activity [inference]

1-alkylglycerophosphocholine O-acetyltransferase activity

lysophospholipid acyltransferase activity

lysophosphatidic acid acyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000176454

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K13512

Name

lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]

References

18458083

Rhea

RHEA:12937

a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA

CoA + a 1,2-diacyl-sn-glycero-3-phosphocholine

Enzyme

2.3.1.23

PMID

RHEA:33191

an acyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine

a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

Enzyme

2.3.1.n6

PMID

RHEA:16245

an acyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine

CoA + 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine

Enzyme

2.3.1.121

PMID

RHEA:32995

an acyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine

CoA + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

Enzyme

2.3.1.n7

PMID

RHEA:18461

1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA

a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

Enzyme

2.3.1.67

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:9256	colorectal cancer	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP005977
Gene Name: lysophosphatidylcholine acyltransferase 4

Ortholog

Displaying entries **51 - 60** of 65 in total

« First

‹ Prev

1

2

3

4

5

6

7

Next ›

Last »
Species	Gene ID	Orthologous MAtrix
Phascolarctos cinereus	110215926	PHACI12550
Saimiri boliviensis boliviensis	101038984	SAIBB25807
Jaculus jaculus	101611857	JACJA24620
Myotis lucifugus	102433872	MYOLU18896
Chlorocebus sabaeus	103245902	CHLSB12798
Rhinopithecus bieti	108518804	RHIBE28321
Rhinopithecus roxellana	104680372	RHIRO29103
Podarcis muralis	114581604	PODMU00535
Sinocyclocheilus grahami	107574180	SINGR101004
Equus asinus asinus	106835136	EQUAS18061

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements