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potassium voltage-gated channel subfamily A member 2

Summary

Gene Symbol

Kcna2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25468

PubChem

25468

Alliance of Genome Resources

RGD:2950

Annotation

Keyword

3D-structure
Cell junction
Cell membrane
Cell projection
Endoplasmic reticulum
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Potassium channel
Reference proteome
Synaptosome
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P63142	RAK RBK2 RCK5 Voltage-gated potassium channel subunit Kv1.2
A6HUS5	Voltage-gated potassium channel subunit Kv1.2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
action potential	IBA
regulation of dopamine secretion	ISS
regulation of dopamine secretion	ISO
neuronal action potential	IMP	12177193
sensory perception of pain	IMP	24472174

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

export across plasma membrane [inference]

potassium ion export across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

export from cell [inference]

export across plasma membrane [inference]

potassium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

developmental process [inference]

anatomical structure arrangement [inference]

cranial nerve structural organization [inference]

optic nerve structural organization

anatomical structure development [inference]

nerve development [inference]

cranial nerve development [inference]

optic nerve development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion export across plasma membrane

export across plasma membrane [inference]

potassium ion export across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

potassium ion export across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of circadian rhythm [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep [inference]

regulation of circadian sleep/wake cycle, non-REM sleep

regulation of cellular process [inference]

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep [inference]

regulation of circadian sleep/wake cycle, non-REM sleep

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential

neuronal action potential

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
endosome	IEA
endoplasmic reticulum membrane	IEA
plasma membrane	ISO
plasma membrane	IMP	2555158
voltage-gated potassium channel complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex

voltage-gated potassium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

lamellipodium membrane

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction [inference]

paranodal junction

leading edge membrane [inference]

lamellipodium membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

juxtaparanode region of axon

cell body membrane [inference]

neuronal cell body membrane

neuron projection terminus [inference]

axon terminus

calyx of Held

presynapse [inference]

axon terminus

calyx of Held

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
voltage-gated potassium channel activity	ISO
voltage-gated potassium channel activity	IDA	1715584 9635436
voltage-gated potassium channel activity	IMP	2555158
delayed rectifier potassium channel activity	IMP	19713757
delayed rectifier potassium channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

kinesin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Potassium channel

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
delayed rectifier potassium channel activity
monoatomic ion channel activity
monoatomic ion transport
potassium channel activity
protein homooligomerization
voltage-gated potassium channel activity

Displaying **all 6** entries
InterPro
BTB/POZ domain
Ion transport domain
Potassium channel tetramerisation-type BTB domain
Potassium channel, voltage dependent, Kv
SKP1/BTB/POZ domain superfamily
Voltage-dependent channel domain superfamily

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3736	Xenbase:XB-GENE-991584
Homo sapiens	3737	Xenbase:XB-GENE-991584	HUMAN51253
Xenopus tropicalis	3738	Xenbase:XB-GENE-991578
Drosophila melanogaster	3739	FB:FBgn0003380
Drosophila melanogaster	3743	FB:FBgn0003380
Drosophila melanogaster	3744	FB:FBgn0003380
Xenopus tropicalis	16485	Xenbase:XB-GENE-991584
Mus musculus	16490	Xenbase:XB-GENE-991584	MOUSE38887
Xenopus tropicalis	16491	Xenbase:XB-GENE-991578
Drosophila melanogaster	16492	FB:FBgn0003380