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proprotein convertase subtilisin/kexin type 6

Summary

Gene Symbol

Pcsk6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25507

PubChem

25507

Alliance of Genome Resources

RGD:3246

Annotation

Keyword

Calcium
Cleavage on pair of basic residues
Glycoprotein
Reference proteome
Repeat
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63415	Paired basic amino acid cleaving enzyme 4 Subtilisin-like proprotein convertase 4 Subtilisin/kexin-like protease PACE4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
proteolysis	IEA
zygotic determination of anterior/posterior axis, embryo	ISO
zygotic determination of anterior/posterior axis, embryo	IEA
determination of left/right symmetry	ISO
determination of left/right symmetry	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glycoprotein metabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular process [inference]

export from cell [inference]

secretion by cell

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

anterior/posterior axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

embryonic pattern specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo [inference]

zygotic determination of anterior/posterior axis, embryo

neurotrophin production [inference]

nerve growth factor production

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell

export from cell [inference]

secretion by cell

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IBA
extracellular space	IEA
cell surface	ISO
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA
serine-type endopeptidase activity	IEA
heparin binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

neurotrophin binding [inference]

nerve growth factor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type 6

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

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InterPro
EGF-like domain
Furin-like repeat
Galactose-binding-like domain superfamily
Growth factor receptor cysteine-rich domain superfamily
Kexin/furin catalytic domain
P domain
PLAC
Peptidase S8, pro-domain superfamily
Peptidase S8, pro-domain
Peptidase S8, subtilisin, Asp-active site

Ortholog

Displaying entries **41 - 50** of 69 in total

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Species	Gene ID	Orthologous MAtrix
Octodon degus	101569107	OCTDE00654
Chrysemys picta bellii	101944031	CHRPI05805
Ictidomys tridecemlineatus	101955844	ICTTR14407
Chinchilla lanigera	102019694	CHILA05433
Capra hircus	102184666	CAPHI13621
Pelodiscus sinensis	102458780	PELSI13531
Astyanax mexicanus	103021799	ASTMX12406
Serinus canaria	103816230	SERCA10496
Esox lucius	105014713	ESOLU03771
Sinocyclocheilus grahami	107563219	SINGR14045

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