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solute carrier family 34 member 1

Summary

Gene Symbol

Slc34a1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25548

PubChem

25548

Alliance of Genome Resources

RGD:3708

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KAT2	Na(+)-dependent phosphate cotransporter 2A Sodium/phosphate cotransporter 2A Solute carrier family 34 member 1
Q06496	Na(+)-dependent phosphate cotransporter 2A Sodium/phosphate cotransporter 2A Solute carrier family 34 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **26 - 30** of 40 in total

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GO Term	Evidence Code	PMID
cellular response to parathyroid hormone stimulus	IEP	16767692
positive regulation of sodium-dependent phosphate transport	IDA IEP IMP	11880379 12739158 16476458
ossification	IEP	17310099
response to thyroid hormone	IEP	10098486
kidney development	IEP	10405196

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

indole-containing compound metabolic process [inference]

indole metabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

cellular aromatic compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

gentamycin metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

glycoprotein metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

gentamycin metabolic process

organic cyclic compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

indole-containing compound metabolic process [inference]

indole metabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

gentamycin metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process

cellular aromatic compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

heterocycle metabolic process [inference]

indole-containing compound metabolic process [inference]

indole metabolic process

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

arsenate ion transmembrane transport

multicellular organismal process [inference]

ossification

tissue remodeling [inference]

bone remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth [inference]

dentinogenesis

anatomical structure formation involved in morphogenesis [inference]

dentinogenesis

anatomical structure development [inference]

animal organ development [inference]

kidney development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular phosphate ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular phosphate ion homeostasis

inorganic ion homeostasis [inference]

phosphate ion homeostasis

intracellular phosphate ion homeostasis

calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to vitamin [inference]

response to vitamin A

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

response to peptide hormone

response to growth hormone

response to parathyroid hormone

cellular response to parathyroid hormone stimulus

response to thyroid hormone

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to chemical [inference]

response to nutrient

response to vitamin [inference]

response to vitamin A

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

response to peptide hormone

response to growth hormone

response to parathyroid hormone

cellular response to parathyroid hormone stimulus

response to thyroid hormone

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to peptide

response to peptide hormone

response to growth hormone

response to organic cyclic compound [inference]

response to estradiol

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

response to lipid [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to inorganic substance [inference]

response to metal ion [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

response to sodium phosphate

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to peptide

response to peptide hormone

response to growth hormone

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to oxygen-containing compound [inference]

response to peptide

response to peptide hormone

response to growth hormone

response to salt [inference]

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to parathyroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic anion transport [inference]

phosphate ion transport

inorganic diphosphate transport

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

phosphate ion transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

arsenate ion transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of phosphate transport [inference]

regulation of sodium-dependent phosphate transport [inference]

positive regulation of sodium-dependent phosphate transport

regulation of phosphate transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of inorganic anion transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of phosphate transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of sodium-dependent phosphate transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of sodium-dependent phosphate transport

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of inorganic anion transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of phosphate transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of inorganic anion transmembrane transport [inference]

positive regulation of phosphate transmembrane transport

regulation of biological quality [inference]

regulation of membrane potential [inference]

positive regulation of membrane potential

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
cell surface	IDA	21865732
nucleoplasm	ISO
brush border	IBA
brush border membrane	IDA	19493963 8691716 9058191
basolateral plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

perinuclear region of cytoplasm

cluster of actin-based cell projections [inference]

brush border

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein-containing complex binding	IPI	21372499
identical protein binding	IPI	17310099 9163330
PDZ domain binding	IPI	15917299
sodium:phosphate symporter activity	IBA IDA IMP ISO ISS	10198426 10370077 10926678 8327470 9058191

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

PDZ domain binding

identical protein binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Sodium-dependent phosphate transport protein

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
inorganic anion transport
intracellular phosphate ion homeostasis
sodium ion transmembrane transport
sodium-dependent phosphate transport

Displaying 1 entry
InterPro
Sodium-dependent phosphate transport protein

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
endosome	PMID:16514432
perinuclear region of cytoplasm	PMID:10449440
brush border membrane	PMID:19493963
apical plasma membrane	PMID:9639577
cell surface	PMID:21865732

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

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DO ID	Disease Name	Source
DOID:0050336	hypophosphatemia	Alliance of Genome Resources
DOID:0050947	hereditary hypophosphatemic rickets with hypercalciuria	Alliance of Genome Resources
DOID:0080077	hypophosphatemic nephrolithiasis/osteoporosis 1	Alliance of Genome Resources
DOID:0080758	Fanconi renotubular syndrome 2	Alliance of Genome Resources
DOID:1062	Fanconi syndrome	Alliance of Genome Resources
DOID:12678	hypercalcemia	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:585	nephrolithiasis	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 89 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Jaculus jaculus	101612597	51337_0:0023b0
Mustela putorius furo	101687536		MUSPF19620
Heterocephalus glaber	101721402	10181_0:00048d	HETGA03583
Mesocricetus auratus	101827429	10036_0:002cb6
Ictidomys tridecemlineatus	101966833	43179_0:003dc8	ICTTR14335
Microtus ochrogaster	101998599	79684_0:0021b6
Chinchilla lanigera	102024651	34839_0:000717	CHILA02339
Macaca fascicularis	102125890		MACFA37081
Myotis lucifugus	102422222		MYOLU00413
Peromyscus maniculatus bairdii	102908436	230844_0:001baf

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OrthoDB (Group)

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Acknowledgements