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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
cholinergic receptor nicotinic alpha 4 subunit
Summary
- Gene Symbol
-
- Chrna4
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Ligand-gated ion channel
- Palmitate
- Phosphoprotein
- Postsynaptic cell membrane
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P09483 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| acetylcholine receptor signaling pathway | ||
| regulation of acetylcholine-gated cation channel activity | ||
| synaptic transmission, cholinergic | ||
| B cell activation | ||
| sensory perception of pain |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| membrane | ||
| postsynaptic membrane | ||
| presynapse | ||
| postsynaptic specialization membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| acetylcholine receptor activity | ||
| acetylcholine-gated monoatomic cation-selective channel activity | ||
| protein-containing complex binding | ||
| heterocyclic compound binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- neuronal acetylcholine receptor subunit alpha-4
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- J: Translation, ribosomal structure and biogenesis
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0060682 | autosomal dominant nocturnal frontal lobe epilepsy 1 | |
| DOID:10652 | Alzheimer's disease | |
| DOID:12217 | Lewy body dementia | |
| DOID:1574 | alcohol use disorder | |
| DOID:3635 | congenital myasthenic syndrome | |
| DOID:6000 | congestive heart failure |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 1137 | HGNC:1958 | HUMAN57884 | ||
| 11438 | 10090_1:000a92 | MGI:87888 | MOUSE31966 | |
| 31767 | FB:FBgn0015519 | |||
| 40521 | FB:FBgn0266347 | |||
| 42918 | FB:FBgn0000036 | |||
| 42919 | FB:FBgn0000039 | |||
| 42920 | FB:FBgn0004118 | |||
| 172105 | WB:WBGene00006774 | |||
| 172150 | WB:WBGene00006797 | |||
| 469999 | PANTR25339 |
