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gamma-aminobutyric acid type A receptor subunit delta

Summary

Gene Symbol

GABRD

Organism

Homo sapiens (human)

External Links

NCBI Gene

2563

PubChem

2563

Alliance of Genome Resources

HGNC:4084

Annotation

Keyword

3D-structure
Cell membrane
Chloride channel
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O14764	GABA(A) receptor subunit delta
A8K496

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
signal transduction	TAS	2176788
gamma-aminobutyric acid signaling pathway	ISS
gamma-aminobutyric acid signaling pathway	NAS	28528665
gamma-aminobutyric acid signaling pathway	IDA	35355020
synaptic transmission, GABAergic	NAS	28528665 35355020

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

signal transduction

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

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GO Term	Evidence Code	PMID
plasma membrane	ISS
axon	IEA
dendrite	IEA
chloride channel complex	IEA
neuron projection

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

GABA receptor complex [inference]

GABA-A receptor complex

membrane protein complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

GABA-ergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

cell body [inference]

neuronal cell body

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GABA-A receptor activity	IBA
chloride channel activity	IBA
protein binding	IPI	16189514 25416956 32296183
neurotransmitter receptor activity
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

GABA receptor activity [inference]

GABA-A receptor activity

neurotransmitter receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gamma-aminobutyric acid receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
GABA-A receptor activity
chemical synaptic transmission
chloride channel activity
chloride transmembrane transport
chloride transport
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
nervous system process
neurotransmitter receptor activity

Displaying **all 8** entries
InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111292	obsolete idiopathic generalized epilepsy 10	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	2560	FB:FBgn0010240
Drosophila melanogaster	2561	FB:FBgn0010240
Drosophila melanogaster	2562	FB:FBgn0010240
Xenopus tropicalis	2563	Xenbase:XB-GENE-988598
Drosophila melanogaster	2568	FB:FBgn0010240
Drosophila melanogaster	2569	FB:FBgn0010240
Drosophila melanogaster	2570	FB:FBgn0010240
Drosophila melanogaster	14400	FB:FBgn0010240
Drosophila melanogaster	14401	FB:FBgn0010240
Drosophila melanogaster	14402	FB:FBgn0010240