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Guidelines

MIRAGE

glucose-6-phosphatase catalytic subunit 1

Summary

Gene Symbol

G6pc1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25634

PubChem

25634

Alliance of Genome Resources

RGD:2644

Annotation

Keyword

Endoplasmic reticulum
Gluconeogenesis
Glycoprotein
Hydrolase
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HJB1
P43428	Glucose-6-phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 26 in total

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GO Term	Evidence Code	PMID
gluconeogenesis	IBA
gluconeogenesis	IEA
triglyceride metabolic process	ISO
steroid metabolic process	ISO
amine metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

amine metabolic process

purine-containing compound metabolic process [inference]

urate metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

urate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate derivative metabolic process [inference]

glucose 6-phosphate metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

amine metabolic process

purine-containing compound metabolic process [inference]

urate metabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

multicellular organismal process [inference]

multicellular organism growth

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

lipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to food

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to carbohydrate

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to organic cyclic compound [inference]

response to stilbenoid [inference]

response to resveratrol

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to food

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to oxygen-containing compound [inference]

response to carbohydrate

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to resveratrol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

organophosphate ester transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

carbohydrate derivative transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IEA
proteasome activator complex	IEA
membrane	ISO
membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

proteasome activator complex

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
glucose-6-phosphatase activity	ISO
glucose-6-phosphatase activity	TAS	8865366
glucose-6-phosphatase activity	IDA	11440903 12757934 4303362 4353083
glucose-6-phosphatase activity	IBA
glucose-6-phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [inference]

primary amine oxidase activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, alcohol group as acceptor

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

sugar-terminal-phosphatase activity [inference]

glucose-6-phosphatase activity

binding [inference]

ion binding [inference]

anion binding [inference]

phosphate ion binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

quinone binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glucose-6-phosphatase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
gluconeogenesis
glucose-6-phosphatase activity
hydrolase activity

Displaying **all 3** entries
InterPro
Glucose-6-phosphatase
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
Phosphatidic acid phosphatase type 2/haloperoxidase

Rhea

H₂O + α-D-glucose 6-phosphate

α-D-glucose + phosphate

Enzyme

H₂O + D-glucose 6-phosphate

D-glucose + phosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Otolemur garnettii	100951220		OTOGA14978
Pan paniscus	100972574		PANPA16583
Papio anubis	101013416		PAPAN14851
Saimiri boliviensis boliviensis	101035032		SAIBB36835
Takifugu rubripes	101070567		TAKRU25250
Felis catus	101101426		FELCA32065
Ovis aries	101106185		SHEEP03119
Gorilla gorilla gorilla	101131213		GORGO34164
Oryzias latipes	101169594		ORYLA20064
Octodon degus	101584942		OCTDE12661

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Last updated: December 8, 2025