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insulin-like growth factor binding protein 1

Summary

Gene Symbol

Igfbp1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25685

PubChem

25685

Alliance of Genome Resources

RGD:2872

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P21743

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
response to organic cyclic compound	IEP	7536658
phosphatidylinositol-mediated signaling	TAS	11942857
response to insulin	ISO
insulin receptor signaling pathway	IEP	11784721
positive regulation of cell growth	IEP	1705004

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

tissue regeneration

growth [inference]

developmental growth [inference]

tissue regeneration

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IEA ISO
extracellular space	IBA IDA ISO	16166214

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
insulin-like growth factor I binding	IBA ISO
insulin-like growth factor binding	ISO TAS	15070850
insulin-like growth factor II binding	IBA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

insulin-like growth factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Insulin-like growth factor-binding protein 1

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
growth factor binding
insulin-like growth factor I binding
insulin-like growth factor II binding
insulin-like growth factor binding
regulation of insulin-like growth factor receptor signaling pathway

Displaying **all 7** entries
InterPro
Growth factor receptor cysteine-rich domain superfamily
Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
Insulin-like growth factor-binding protein 1
Insulin-like growth factor-binding protein family 1-6, chordata
Insulin-like growth factor-binding protein, IGFBP
Thyroglobulin type-1 superfamily
Thyroglobulin type-1

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:16166214

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11713	diabetic angiopathy	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 100** of **123** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Salmo trutta	115169641		SALTR40595
Salmo trutta	115192278		SALTR28087
Salarias fasciatus	115381209		SALFA43120
Salarias fasciatus	115405555		SALFA32426
Gadus morhua	115549534		GADMO59231
Gadus morhua	115556190		GADMO07502
Sparus aurata	115571945		SPAAU38176
Strigops habroptila	115611399		STRHB16105
Mastomys coucha	116069993	35658_0:0031c9
Corvus moneduloides	116441232		CORMO08462

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements