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5-hydroxytryptamine receptor 5A

Summary

Gene Symbol

Htr5a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25689

PubChem

25689

Alliance of Genome Resources

RGD:2851

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KJK9
P35364	REC17 Serotonin receptor 5A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
hippocampus development	IEP	16572590
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA IMP	10861802
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA ISO ISS
adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO
chemical synaptic transmission	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

developmental process [inference]

anatomical structure development [inference]

hippocampus development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
postsynaptic specialization membrane	IDA	16082681
perikaryon	IDA	15282708
plasma membrane	IBA ISO ISS
dendrite	IBA IDA	17394137

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	ISO ISS
serotonin receptor activity	IEA ISO
neurotransmitter receptor activity	IBA
G protein-coupled serotonin receptor activity	IBA IMP ISO	7682702
serotonin binding	IBA

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

5-hydroxytryptamine receptor 5A

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 6** entries
Gene Ontology
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
G protein-coupled serotonin receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
chemical synaptic transmission
neurotransmitter receptor activity
serotonin binding

Displaying **all 4** entries
InterPro
5-Hydroxytryptamine 5A receptor
5-hydroxytryptamine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
perikaryon	PMID:15282708
dendrite	PMID:17394137

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9428	intracranial hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **105** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ictidomys tridecemlineatus	101960290	43179_0:002559	ICTTR02559
Microtus ochrogaster	101985573	79684_0:00406a
Chinchilla lanigera	102017028	34839_0:003b2a	CHILA19482
Macaca fascicularis	102129180		MACFA30762
Latimeria chalumnae	102362968		LATCH06498
Peromyscus maniculatus bairdii	102927486	230844_0:0012bf
Astyanax mexicanus	103024346		ASTMX13123
Astyanax mexicanus	103047601		ASTMX08021
Chlorocebus sabaeus	103227281		CHLSB10206
Carlito syrichta	103270932		CARSF00915

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements