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cyclin G associated kinase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

2580

PubChem

2580

Alliance of Genome Resources

HGNC:4113

JoGo

GAK

TogoVar

GAK

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Cell junction
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Kinase
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DS37
O14976	DnaJ homolog subfamily C member 26

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
receptor-mediated endocytosis	IMP	16155256
endoplasmic reticulum organization	ISS
Golgi organization	IMP	16155256 24510904
negative regulation of neuron projection development	IDA	24510904

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

'de novo' protein folding [inference]

'de novo' post-translational protein folding [inference]

chaperone cofactor-dependent protein refolding

chaperone-mediated protein folding [inference]

chaperone cofactor-dependent protein refolding

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

clathrin-dependent endocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

cellular localization [inference]

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

synaptic vesicle uncoating

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly

synaptic vesicle uncoating

protein-containing complex assembly [inference]

clathrin coat assembly

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

clathrin-dependent endocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

clathrin-dependent endocytosis

establishment of localization in cell [inference]

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

cellular localization [inference]

intracellular transport

vacuolar transport [inference]

Golgi to vacuole transport [inference]

Golgi to lysosome transport

lysosomal transport [inference]

Golgi to lysosome transport

cytosolic transport [inference]

Golgi to lysosome transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of clathrin coat assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

regulation of protein-containing complex assembly [inference]

regulation of clathrin coat assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
Golgi apparatus	IDA	16155256
cytosol	TAS
focal adhesion	IEA
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	TAS	9299234
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA
AMP-activated protein kinase activity	IEA
eukaryotic translation initiation factor 2alpha kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein kinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
AP-2 adaptor complex binding
ATP binding
positive regulation of Notch signaling pathway
regulation of clathrin-dependent endocytosis

Displaying **all 8** entries
InterPro
C2 domain superfamily
Chaperone J-domain superfamily
DnaJ domain
Protein kinase domain
Protein kinase-like domain superfamily
Protein-tyrosine phosphatase-like
Serine/threonine-protein kinase, active site
Tensin phosphatase, C2 domain

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements