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TTL family tubulin polyglutamylase complex subunit L1

Summary

Gene Symbol

TTLL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

25809

PubChem

25809

Alliance of Genome Resources

HGNC:1312

Annotation

Keyword

ATP-binding
Alternative splicing
Cytoskeleton
Flagellum
Ligase
Magnesium
Metal-binding
Microtubule
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O95922	Tubulin polyglutamylase TTLL1 Tubulin polyglutamylase complex subunit 3 Tubulin--tyrosine ligase-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IDA	34782749
immune response in nasopharyngeal-associated lymphoid tissue	IEA
sperm axoneme assembly	IBA
protein polyglutamylation	TAS	15890843
cerebellar Purkinje cell differentiation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

immune response in gut-associated lymphoid tissue [inference]

immune response in nasopharyngeal-associated lymphoid tissue

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein polyglutamylation

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

mucociliary clearance

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

cellular component assembly [inference]

axoneme assembly [inference]

sperm axoneme assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

multicellular organismal process [inference]

system process [inference]

respiratory system process [inference]

mucociliary clearance

developmental process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

response to stimulus [inference]

immune response [inference]

immune response in gut-associated lymphoid tissue [inference]

immune response in nasopharyngeal-associated lymphoid tissue

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

mucociliary clearance

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

mucociliary clearance

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of blastocyst development

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	IEA
microtubule	IDA	34782749
motile cilium	IEA
ciliary basal body	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
tubulin binding	IBA
metal ion binding	IEA
tubulin-glutamic acid ligase activity	TAS	15890843
tubulin-glutamic acid ligase activity	IDA	34782749

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

acid-amino acid ligase activity [inference]

protein-glutamic acid ligase activity [inference]

catalytic activity, acting on a protein [inference]

protein-glutamic acid ligase activity [inference]

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tubulin--tyrosine ligase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
microtubule cytoskeleton organization
nucleotide binding
tubulin binding
tubulin-glutamic acid ligase activity

Displaying 1 entry
InterPro
Tubulin-tyrosine ligase/Tubulin polyglutamylase

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	25809	Xenbase:XB-GENE-920807
Mus musculus	319953		MOUSE15292
Rattus norvegicus	362969		RATNO37990
Danio rerio	393994		DANRE33614
Bos taurus	539530		BOVIN30816
Macaca mulatta	714668		MACMU02310
Monodelphis domestica	100011528		MONDO34587
Equus caballus	100056216		HORSE25876
Ornithorhynchus anatinus	100076725		ORNAN05716
Taeniopygia guttata	100219185		TAEGU08102