Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
Resources Genes Glycoproteins Lectins Glycolipids Glycans Pathways Diseases Organisms
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Other Information
Release Statistics Download
Tools
SugarDrawer GlycanBuilder Glycan Converters GlycoMaple GlycomeAtlas LM-GlycomeAtlas GALAXY MCAW GlycoSim GRable
Search Tools
Cross Search Glycan Search Publication Search Programmatic Access
Standards Ontologies Notations
Guidelines
MIRAGE
UDP-galactose-4-epimerase

Summary
Gene Symbol
  • GALE
Aliases
  • SDR1E1
  • UDP-glucose 4-epimerase
  • short chain dehydrogenase/reductase family 1E, member 1
Organism
Homo sapiens (human)
NCBI Gene
2582
HGNC
4116
KEGG Gene ID
hsa:2582
PubChem
2582
Alliance of Genome Resources
JoGo
GALE
TogoVar
GALE
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Disease variant
  • Galactose metabolism
  • Isomerase
  • NAD
  • Proteomics identification
  • Reference proteome
Proteins
Displaying all 2 entries
UniProt Protein Name
Q14376
  • Galactowaldenase
  • UDP-N-acetylgalactosamine 4-epimerase
  • UDP-N-acetylglucosamine 4-epimerase
  • UDP-galactose 4-epimerase
A0A384NL38
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 2 entries
GO Term Evidence Code PMID
galactose catabolic process
galactose catabolic process via UDP-galactose
GO Hierarchy
Displaying all 2 entries
GO Term Evidence Code PMID
cytosol
cytosol
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
udp-glucose 4-epimerase
Functional Category
  • G: Carbohydrate transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • T: Signal transduction mechanisms
Displaying all 4 entries
Gene Ontology
UDP-glucose 4-epimerase activity
galactose catabolic process via UDP-galactose
galactose metabolic process
isomerase activity
Displaying all 2 entries
InterPro
NAD(P)-binding domain superfamily
UDP-glucose 4-epimerase
KEGG BRITE Database
Orthology
K01784
Name
UDP-glucose 4-epimerase [EC:5.1.3.2]
References
Rhea

RHEA:22168

UDP-α-D-glucose
UDP-α-D-galactose
Enzyme
PMID

RHEA:20517

UDP-N-acetyl-α-D-glucosamine
UDP-N-acetyl-α-D-galactosamine
Enzyme
PMID
Disease
Disease Ontology
Displaying all 2 entries
DO ID Disease Name Source
DOID:0111458 galactose epimerase deficiency
DOID:1588 thrombocytopenia
The Human Phenotype Ontology
Displaying entries 1 - 10 of 18 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000407 Sensorineural hearing impairment
HP:0000750 Delayed speech and language development
HP:0000952 Jaundice
HP:0001249 Intellectual disability
HP:0001252 Hypotonia
HP:0001263 Global developmental delay
HP:0001290 Generalized hypotonia
HP:0001508 Failure to thrive
HP:0001744 Splenomegaly
Displaying 1 entry
Disease ID Disease Name
OMIM:230350
  • galactose epimerase deficiency
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
About Release Notes Help Feedback
International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International

GlyCosmos Portal v4.4.0

Last updated: December 8, 2025