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Guidelines

MIRAGE

chordin like 2

Summary

Gene Symbol

CHRDL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

25884

PubChem

25884

Alliance of Genome Resources

HGNC:24168

Annotation

Keyword

Alternative splicing
Chondrogenesis
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Glycoprotein
Osteogenesis
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6WN34	Breast tumor novel factor 1 Chordin-related protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ossification	IEA
cell differentiation	IBA
negative regulation of BMP signaling pathway	IBA
cartilage development	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cartilage development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	HDA	16502470
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
BMP binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

BMP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

von Willebrand factor C domain-containing protein 2-like

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism

Displaying **all 2** entries
Gene Ontology
BMP binding
cell differentiation

Displaying **all 2** entries
InterPro
Chordin-like protein 1/2
VWFC domain

Ortholog

Displaying entries **1 - 10** of 70 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	25884	ZFIN:ZDB-GENE-081104-305
Mus musculus	69121	ZFIN:ZDB-GENE-081104-305	MOUSE55256
Rattus norvegicus	308854		RATNO15606
Pan troglodytes	466898		PANTR03822
Bos taurus	533631		BOVIN07232
Danio rerio	563085		DANRE21239
Canis lupus familiaris	609312		CANLF08270
Macaca mulatta	693657		MACMU11480
Monodelphis domestica	100013105		MONDO24561
Equus caballus	100065017		HORSE38066

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025