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methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like

Summary

Gene Symbol

MTHFD1L

Organism

Homo sapiens (human)

External Links

NCBI Gene

25902

PubChem

25902

Alliance of Genome Resources

HGNC:21055

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Direct protein sequencing
Ligase
Mitochondrion
One-carbon metabolism
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A087WVM4
B2RD24
Q6UB35	Formyltetrahydrofolate synthetase
B7ZM99

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
neural tube closure	ISS
folic acid-containing compound metabolic process	IDA	12937168
10-formyltetrahydrofolate biosynthetic process	IDA	12937168
10-formyltetrahydrofolate biosynthetic process	IBA
formate metabolic process	IDA	16171773

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

formate metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

formate metabolic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

one-carbon metabolic process [inference]

tetrahydrofolate interconversion

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

formate metabolic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

one-carbon metabolic process [inference]

tetrahydrofolate interconversion

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

formate metabolic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organic cyclic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

formate metabolic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

one-carbon metabolic process [inference]

tetrahydrofolate interconversion

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA	12937168
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
formate-tetrahydrofolate ligase activity	IDA	12937168
formate-tetrahydrofolate ligase activity	IBA
methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEA
ATP binding	IDA	16171773
protein homodimerization activity	IDA	16171773

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [inference]

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity [inference]

methylenetetrahydrofolate dehydrogenase (NADP+) activity

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

formate-tetrahydrofolate ligase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

formate-tetrahydrofolate ligase

Functional Category

F: Nucleotide transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 2** entries
Gene Ontology
ATP binding
formate-tetrahydrofolate ligase activity

Displaying **all 2** entries
InterPro
Formate-tetrahydrofolate ligase, FTHFS
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080074	neural tube defect	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	4522	SGD:S000003436
Xenopus tropicalis	25902	Xenbase:XB-GENE-1011645
Saccharomyces cerevisiae S288C	108156	SGD:S000000288
Mus musculus	270685		MOUSE01394
Rattus norvegicus	361472		RATNO15981
Bos taurus	534296		BOVIN35986
Macaca mulatta	705222		MACMU35395
Monodelphis domestica	100032106		MONDO10968
Danio rerio	100034522		DANRE19777
Equus caballus	100063441		HORSE29672